A preclinical murine model of hepatic metastases

Kevin C. Soares, Kelly Foley, Kelly Olino, Ashley Leubner, Skye C. Mayo, Ajay Jain, Richard D. Schulick, Elizabeth Jaffee, Kiyoshi Yoshimura, Barish Edil, Lei Zheng

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

Original languageEnglish (US)
Article numbere51677
JournalJournal of Visualized Experiments
Issue number91
DOIs
StatePublished - Sep 27 2014
Externally publishedYes

Fingerprint

Tumors
Neoplasm Metastasis
Liver
Immunology
Neoplasms
Oncology
Cells
Investigational Therapies
Allergy and Immunology
Testing
Liver Diseases
Injections
Research
Therapeutics

Keywords

  • Hemispleen
  • Hepatic Metastases
  • Immunotherapy
  • Issue 91
  • Liver
  • Medicine
  • Metastatic
  • Murine
  • Pancreatic Cancer
  • Pancreatic Neoplasms
  • Preclinical Model

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemical Engineering(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Soares, K. C., Foley, K., Olino, K., Leubner, A., Mayo, S. C., Jain, A., ... Zheng, L. (2014). A preclinical murine model of hepatic metastases. Journal of Visualized Experiments, (91), [e51677]. https://doi.org/10.3791/51677

A preclinical murine model of hepatic metastases. / Soares, Kevin C.; Foley, Kelly; Olino, Kelly; Leubner, Ashley; Mayo, Skye C.; Jain, Ajay; Schulick, Richard D.; Jaffee, Elizabeth; Yoshimura, Kiyoshi; Edil, Barish; Zheng, Lei.

In: Journal of Visualized Experiments, No. 91, e51677, 27.09.2014.

Research output: Contribution to journalArticle

Soares, KC, Foley, K, Olino, K, Leubner, A, Mayo, SC, Jain, A, Schulick, RD, Jaffee, E, Yoshimura, K, Edil, B & Zheng, L 2014, 'A preclinical murine model of hepatic metastases', Journal of Visualized Experiments, no. 91, e51677. https://doi.org/10.3791/51677
Soares KC, Foley K, Olino K, Leubner A, Mayo SC, Jain A et al. A preclinical murine model of hepatic metastases. Journal of Visualized Experiments. 2014 Sep 27;(91). e51677. https://doi.org/10.3791/51677
Soares, Kevin C. ; Foley, Kelly ; Olino, Kelly ; Leubner, Ashley ; Mayo, Skye C. ; Jain, Ajay ; Schulick, Richard D. ; Jaffee, Elizabeth ; Yoshimura, Kiyoshi ; Edil, Barish ; Zheng, Lei. / A preclinical murine model of hepatic metastases. In: Journal of Visualized Experiments. 2014 ; No. 91.
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