A preclinical murine model of hepatic metastases

Kevin C. Soares, Kelly Foley, Kelly Olino, Ashley Leubner, Skye C. Mayo, Ajay Jain, Richard D. Schulick, Elizabeth Jaffee, Kiyoshi Yoshimura, Barish Edil, Lei Zheng

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Numerous murine models have been developed to study human cancers and advance the understanding of cancer treatment and development. Here, a preclinical, murine pancreatic tumor model of hepatic metastases via a hemispleen injection of syngeneic murine pancreatic tumor cells is described. This model mimics many of the clinical conditions in patients with metastatic disease to the liver. Mice consistently develop metastases in the liver allowing for investigation of the metastatic process, experimental therapy testing, and tumor immunology research.

Original languageEnglish (US)
Article numbere51677
JournalJournal of Visualized Experiments
Issue number91
DOIs
StatePublished - Sep 27 2014

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Keywords

  • Hemispleen
  • Hepatic Metastases
  • Immunotherapy
  • Issue 91
  • Liver
  • Medicine
  • Metastatic
  • Murine
  • Pancreatic Cancer
  • Pancreatic Neoplasms
  • Preclinical Model

ASJC Scopus subject areas

  • Neuroscience(all)
  • Chemical Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Soares, K. C., Foley, K., Olino, K., Leubner, A., Mayo, S. C., Jain, A., Schulick, R. D., Jaffee, E., Yoshimura, K., Edil, B., & Zheng, L. (2014). A preclinical murine model of hepatic metastases. Journal of Visualized Experiments, (91), [e51677]. https://doi.org/10.3791/51677