A proposed system for scoring structural aberrations detected by chromosome painting

J. D. Tucker, W. F. Morgan, A. A. Awa, M. Bauchinger, D. Blakey, Michael Cornforth, L. G. Littlefield, A. T. Natarajan, C. Shasserre

Research output: Contribution to journalArticle

293 Citations (Scopus)

Abstract

The advent of chromosome painting has brought the realization that structural aberrations can be far more complicated than previously imagined. Various investigators have devised their own nomenclature systems to deal with this difficulty, with the result that the terminology has become inconsistent and confusing. Recently, an international group of cytogeneticists experienced in chromosome painting gathered to address this issue. Results of the meeting are presented in this report, which provides a nomenclature system capable of describing chromosome aberrations that occur between painted and unpainted chromosomes, as well as aberrations involving only painted chromosomes. The nomenclature is flexible enough to describe accurately even the most extensively rearranged chromosomes. As a consequence of this flexibility, the scheme upon which the nomenclature is based differs substantially from other systems of aberration classification We call this system the Protocol for Aberration Identification and Nomenclature Terminology (PAINT).

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalCytogenetics and Cell Genetics
Volume68
Issue number3-4
StatePublished - 1995
Externally publishedYes

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Chromosome Painting
Terminology
Chromosomes
Chromosome Aberrations
Research Personnel

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

Cite this

Tucker, J. D., Morgan, W. F., Awa, A. A., Bauchinger, M., Blakey, D., Cornforth, M., ... Shasserre, C. (1995). A proposed system for scoring structural aberrations detected by chromosome painting. Cytogenetics and Cell Genetics, 68(3-4), 211-221.

A proposed system for scoring structural aberrations detected by chromosome painting. / Tucker, J. D.; Morgan, W. F.; Awa, A. A.; Bauchinger, M.; Blakey, D.; Cornforth, Michael; Littlefield, L. G.; Natarajan, A. T.; Shasserre, C.

In: Cytogenetics and Cell Genetics, Vol. 68, No. 3-4, 1995, p. 211-221.

Research output: Contribution to journalArticle

Tucker, JD, Morgan, WF, Awa, AA, Bauchinger, M, Blakey, D, Cornforth, M, Littlefield, LG, Natarajan, AT & Shasserre, C 1995, 'A proposed system for scoring structural aberrations detected by chromosome painting', Cytogenetics and Cell Genetics, vol. 68, no. 3-4, pp. 211-221.
Tucker JD, Morgan WF, Awa AA, Bauchinger M, Blakey D, Cornforth M et al. A proposed system for scoring structural aberrations detected by chromosome painting. Cytogenetics and Cell Genetics. 1995;68(3-4):211-221.
Tucker, J. D. ; Morgan, W. F. ; Awa, A. A. ; Bauchinger, M. ; Blakey, D. ; Cornforth, Michael ; Littlefield, L. G. ; Natarajan, A. T. ; Shasserre, C. / A proposed system for scoring structural aberrations detected by chromosome painting. In: Cytogenetics and Cell Genetics. 1995 ; Vol. 68, No. 3-4. pp. 211-221.
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