A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers

Jon B. Bishop, Linda G. Phillips, Thomas A. Mustoe, A. John VanderZee, Laurel Wiersema, Dell E. Roach, John P. Heggers, Donald P. Hill, Eugene L. Taylor, Martin C. Robson

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Chronic wounds such as venous stasis ulcers have become a socioeconomic problem. Even with successful initial management, the recurrence rate approaches 70%. With the advent of new wound healing agents, nonoperative attempts to heal these wounds appear indicated. This study reports a prospective randomized evaluator-blinded trial comparing two potential wound healing agents to an inert vehicle placebo. Eighty-six evaluable patients completed the trial. Silver sulfadiazine 1% in a cream proved to statistically reduce the ulcer size compared with a biologically active tripeptide copper complex 0.4% cream formulation or the placebo. There was no difference between the latter two treatments. Silver sulfadiazine has been shown to allow keratinocyte replication and to have antiinflammatory properties. In this trial its antibacterial action was not used since all ulcers had comparable bacterial levels (≤ 105/gm of tissue) before treatment. These results suggest that the silver sulfadiazine cream used in this study may facilitate healing in wounds healing largely by the process of epithelization.

Original languageEnglish (US)
Pages (from-to)251-257
Number of pages7
JournalJournal of vascular surgery
Volume16
Issue number2
DOIs
StatePublished - Aug 1992
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

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    Bishop, J. B., Phillips, L. G., Mustoe, T. A., VanderZee, A. J., Wiersema, L., Roach, D. E., Heggers, J. P., Hill, D. P., Taylor, E. L., & Robson, M. C. (1992). A prospective randomized evaluator-blinded trial of two potential wound healing agents for the treatment of venous stasis ulcers. Journal of vascular surgery, 16(2), 251-257. https://doi.org/10.1016/0741-5214(92)90115-O