A Prospective Three-Year Cohort Study of the Epidemiology and Virology of Acute Respiratory Infections of Children in Rural India

Shobha Broor, Shama Parveen, Preeti Bharaj, Velisetty S. Prasad, Kavalu N. Srinivasulu, Krishna M. Sumanth, Suresh Kumar Kapoor, Karen Fowler, Wayne M. Sullender

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Abstract

Background:Acute respiratory infection (ARI) is a major killer of children in developing countries. Although the frequency of ARI is similar in both developed and developing countries, mortality due to ARI is 10-50 times higher in developing countries. Viruses are common causes of ARI among such children, yet the disease burden of these infections in rural communities is unknown.Methodology/Principal Findings:A prospective longitudinal study was carried out in children enrolled from two rural Indian villages at birth and followed weekly for the development of ARI, classified as upper respiratory infection, acute lower respiratory infection (ALRI), or severe ALRI. Respiratory syncytial virus (RSV), influenza, parainfluenza viruses and adenoviruses in nasopharyngeal aspirates were detected by direct fluorescent antibody testing (DFA) and, in addition, centrifugation enhanced culture for RSV was done. 281 infants enrolled in 39 months and followed until 42 months. During 440 child years of follow-up there were 1307 ARIs, including 236 ALRIs and 19 severe ALRIs. Virus specific incidence rates per 1000 child years for RSV were total ARI 234, ALRI 39, and severe ALRI 9; for influenza A total ARI 141, ALRI 39; for INF B total ARI 37; for PIV1 total ARI 23, for PIV2 total ARI 28, ALRI 5; for parainfluenza virus 3 total ARI 229, ALRI 48, and severe ALRI 5 and for adenovirus total ARI 18, ALRI 5. Repeat infections with RSV were seen in 18 children.Conclusions/Significance:RSV, influenza A and parainfluenza virus 3 were important causes of ARI among children in rural communities in India. These data will be useful for vaccine design, development and implementation purposes.

Original languageEnglish (US)
Article numbere491
JournalPLoS One
Volume2
Issue number6
DOIs
StatePublished - 2007
Externally publishedYes

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virology
Epidemiology
Virology
cohort studies
Viruses
Respiratory Tract Infections
epidemiology
India
Cohort Studies
infection
Developing countries
Respiratory Syncytial Viruses
viruses
Developing Countries
Centrifugation
Paramyxoviridae Infections
developing countries
Rural Population
rural communities
Adenoviridae

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Broor, S., Parveen, S., Bharaj, P., Prasad, V. S., Srinivasulu, K. N., Sumanth, K. M., ... Sullender, W. M. (2007). A Prospective Three-Year Cohort Study of the Epidemiology and Virology of Acute Respiratory Infections of Children in Rural India. PLoS One, 2(6), [e491]. https://doi.org/10.1371/journal.pone.0000491

A Prospective Three-Year Cohort Study of the Epidemiology and Virology of Acute Respiratory Infections of Children in Rural India. / Broor, Shobha; Parveen, Shama; Bharaj, Preeti; Prasad, Velisetty S.; Srinivasulu, Kavalu N.; Sumanth, Krishna M.; Kapoor, Suresh Kumar; Fowler, Karen; Sullender, Wayne M.

In: PLoS One, Vol. 2, No. 6, e491, 2007.

Research output: Contribution to journalArticle

Broor, S, Parveen, S, Bharaj, P, Prasad, VS, Srinivasulu, KN, Sumanth, KM, Kapoor, SK, Fowler, K & Sullender, WM 2007, 'A Prospective Three-Year Cohort Study of the Epidemiology and Virology of Acute Respiratory Infections of Children in Rural India', PLoS One, vol. 2, no. 6, e491. https://doi.org/10.1371/journal.pone.0000491
Broor, Shobha ; Parveen, Shama ; Bharaj, Preeti ; Prasad, Velisetty S. ; Srinivasulu, Kavalu N. ; Sumanth, Krishna M. ; Kapoor, Suresh Kumar ; Fowler, Karen ; Sullender, Wayne M. / A Prospective Three-Year Cohort Study of the Epidemiology and Virology of Acute Respiratory Infections of Children in Rural India. In: PLoS One. 2007 ; Vol. 2, No. 6.
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AU - Prasad, Velisetty S.

AU - Srinivasulu, Kavalu N.

AU - Sumanth, Krishna M.

AU - Kapoor, Suresh Kumar

AU - Fowler, Karen

AU - Sullender, Wayne M.

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