A protein interaction network analysis for yeast integral membrane protein

Ming Guang Shi, De Shuang Huang, Xue Ling Li

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Although the yeast Saccharomyces cerevisiae is the best exemplified single-celled eukaryote, the vast number of protein-protein interactions of integral membrane proteins of Saccharomyces cerevisiae have not been characterized by experiments. Here, based on the kernel method of Greedy Kernel Principal Component analysis plus Linear Discriminant Analysis, we identify 300 protein-protein interactions involving 189 membrane proteins and get the outcome of a highly connected protein-protein interactions network. Furthermore, we study the global topological features of integral membrane proteins network of Saccharomyces cerevisiae. These results give the comprehensive description of protein-protein interactions of integral membrane proteins and reveal global topological and robustness of the interactome network at a system level. This work represents an important step towards a comprehensive understanding of yeast protein interactions.

Original languageEnglish (US)
Pages (from-to)692-699
Number of pages8
JournalProtein and Peptide Letters
Volume15
Issue number7
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Protein Interaction Maps
Electric network analysis
Yeast
Membrane Proteins
Yeasts
Proteins
Saccharomyces cerevisiae
Fungal Proteins
Discriminant Analysis
Principal Component Analysis
Eukaryota
Discriminant analysis
Principal component analysis

Keywords

  • GPCA
  • LDA
  • Membrane protein
  • Topological features

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

A protein interaction network analysis for yeast integral membrane protein. / Shi, Ming Guang; Huang, De Shuang; Li, Xue Ling.

In: Protein and Peptide Letters, Vol. 15, No. 7, 07.2008, p. 692-699.

Research output: Contribution to journalArticle

Shi, Ming Guang ; Huang, De Shuang ; Li, Xue Ling. / A protein interaction network analysis for yeast integral membrane protein. In: Protein and Peptide Letters. 2008 ; Vol. 15, No. 7. pp. 692-699.
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