A Quantitative Structure-Property Relationship for Predicting Drug Solubility in PEG 400/Water Cosolvent Systems

Keyphrases

• Drug Solubility 100%
• Co-solvent System 100%
• Quantitative Structure-property Relationship 100%
• Polyethylene Glycol 400 100%
• Hydrogen Donor 33%
• Relationship-based 33%
• Log-linear Model 33%
• Chemical Structure 16%
• Predictive Tool 16%
• Training Set 16%
• Linear Regression 16%
• Selection Strategy 16%
• Correlation Coefficient 16%
• Volume Fraction 16%
• Multiple Linear Regression Model 16%
• Polyethylene Glycol 16%
• Radius of Gyration 16%
• Guide Selection 16%
• Root Mean Square Error 16%
• Rotatable Bonds 16%
• Cosolvency Models 16%
• Genetic Algorithm 16%
• In Vivo Preclinical Studies 16%
• Number Density 16%
• Aqueous Solubility 16%
• Binary Mixture 16%
• Shake-flask Method 16%
• Molecular Descriptors 16%
• Vehicle Identification 16%
• Solubility Data 16%
• Log-linear 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Hydrogen Bond 100%
• Macrogol 400 100%
• Drug Solubility 100%
• Macrogol 50%