A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma

Sanjiv Sur, A. A. Mohiuddin, P. Vichyanond, H. S. Nelson

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the ''morning dipping'' in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.

Original languageEnglish (US)
Pages (from-to)384-388
Number of pages5
JournalAnnals of Allergy
Volume65
Issue number5
StatePublished - 1990
Externally publishedYes

Fingerprint

Albuterol
Atropine
Asthma
Peak Expiratory Flow Rate
Bronchodilator Agents
Placebos
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma. / Sur, Sanjiv; Mohiuddin, A. A.; Vichyanond, P.; Nelson, H. S.

In: Annals of Allergy, Vol. 65, No. 5, 1990, p. 384-388.

Research output: Contribution to journalArticle

Sur, S, Mohiuddin, AA, Vichyanond, P & Nelson, HS 1990, 'A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma', Annals of Allergy, vol. 65, no. 5, pp. 384-388.
Sur, Sanjiv ; Mohiuddin, A. A. ; Vichyanond, P. ; Nelson, H. S. / A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma. In: Annals of Allergy. 1990 ; Vol. 65, No. 5. pp. 384-388.
@article{45b44b88257348dca5c55f8130df15a6,
title = "A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma",
abstract = "The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the ''morning dipping'' in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.",
author = "Sanjiv Sur and Mohiuddin, {A. A.} and P. Vichyanond and Nelson, {H. S.}",
year = "1990",
language = "English (US)",
volume = "65",
pages = "384--388",
journal = "Annals of Allergy, Asthma and Immunology",
issn = "1081-1206",
publisher = "American College of Allergy, Asthma and Immunology",
number = "5",

}

TY - JOUR

T1 - A random double-blind trial of the combination of nebulized atropine methylnitrate and albuterol in nocturnal asthma

AU - Sur, Sanjiv

AU - Mohiuddin, A. A.

AU - Vichyanond, P.

AU - Nelson, H. S.

PY - 1990

Y1 - 1990

N2 - The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the ''morning dipping'' in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.

AB - The combination of nebulized atropine methylnitrate (AMN) and a beta-agonist has been shown to produce greater and longer lasting bronchodilation than either drug alone. We examined the efficacy of the combination in diminishing the ''morning dipping'' in PEFR in eight hospitalized but stable asthmatics. The patients received nebulized albuterol along with either AMN (AMN + ALB) or placebo (ALB) in a random double-blind cross-over fashion at 10 PM on four nights. PEFR and FEV1 were recorded at 6 PM, 10 PM, and 6 AM before the administration of bronchodilators. There was no statistically significant difference between ALB and AMN + ALB in reducing the morning dipping in these patients.

UR - http://www.scopus.com/inward/record.url?scp=0025203356&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025203356&partnerID=8YFLogxK

M3 - Article

VL - 65

SP - 384

EP - 388

JO - Annals of Allergy, Asthma and Immunology

JF - Annals of Allergy, Asthma and Immunology

SN - 1081-1206

IS - 5

ER -