A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection

K. Kieburtz, D. Simpson, C. Yiannoutsos, M. B. Max, C. D. Hall, R. J. Ellis, C. M. Marra, R. McKendall, E. Singer, G. J. Dal Pan, D. B. Clifford, T. Tucker, B. Cohen

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Abstract

Background: Painful sensory neuropathy is a common complication of HIV infection. Based on prior uncontrolled observations, we hypothesized that amitriptyline or mexiletine would improve the pain symptoms. Method: A randomized, double-blind, 10-week trial of 145 patients assigned equally to amitriptyline, mexiletine, or matching placebo. The primary outcome measure was the change in pain intensity between baseline and the final visit. Results: The improvement in amitriptyline group (0.31 ± 0.31 units [mean ± SD]) and mexiletine group (0.23 ± 0.41) was not significantly different from placebo (0.20 ± 0.30). Both interventions were generally well tolerated. Conclusions: Neither amitriptyline nor mexiletine provide significant pain relief in patients with HIV-associated painful sensory neuropathy.

Original languageEnglish (US)
Pages (from-to)1682-1688
Number of pages7
JournalNeurology
Volume51
Issue number6
StatePublished - Dec 1998

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ASJC Scopus subject areas

  • Neuroscience(all)

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Kieburtz, K., Simpson, D., Yiannoutsos, C., Max, M. B., Hall, C. D., Ellis, R. J., Marra, C. M., McKendall, R., Singer, E., Dal Pan, G. J., Clifford, D. B., Tucker, T., & Cohen, B. (1998). A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. Neurology, 51(6), 1682-1688.