A rapid method for the inactivation of virus infectivity prior to assay for interferons

Alan Barrett, N. Hunt, N. J. Dimmock

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Virus infectivity in samples of culture medium or suspensions of animal tissue which are required for interferon assay can be rapidly and conveniently inactivated by overnight incubation with beta-propiolactone (BPL). As BPL hydrolyses spontaneously samples can be assayed with no further treatment. BPL does not affect the interfering activity of a, β or γ mouse interferons.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalJournal of Virological Methods
Volume8
Issue number4
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Propiolactone
Virus Inactivation
Interferons
Culture Media
Suspensions
Viruses

Keywords

  • assay of interferons α, β, γ
  • beta-propiolactone
  • inactivation of virus

ASJC Scopus subject areas

  • Virology

Cite this

A rapid method for the inactivation of virus infectivity prior to assay for interferons. / Barrett, Alan; Hunt, N.; Dimmock, N. J.

In: Journal of Virological Methods, Vol. 8, No. 4, 1984, p. 349-351.

Research output: Contribution to journalArticle

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