A rapid method for the inactivation of virus infectivity prior to assay for interferons

Alan Barrett, N. Hunt, N. J. Dimmock

Research output: Contribution to journalArticle

18 Scopus citations


Virus infectivity in samples of culture medium or suspensions of animal tissue which are required for interferon assay can be rapidly and conveniently inactivated by overnight incubation with beta-propiolactone (BPL). As BPL hydrolyses spontaneously samples can be assayed with no further treatment. BPL does not affect the interfering activity of a, β or γ mouse interferons.

Original languageEnglish (US)
Pages (from-to)349-351
Number of pages3
JournalJournal of Virological Methods
Issue number4
StatePublished - 1984
Externally publishedYes



  • assay of interferons α, β, γ
  • beta-propiolactone
  • inactivation of virus

ASJC Scopus subject areas

  • Virology

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