A recombinant envelope protein-based enzyme-linked immunosorbent assay for West Nile virus serodiagnosis.

Tian Wang, Louis A. Magnarelli, John F. Anderson, L. Hannah Gould, Sandra L. Bushmich, Susan J. Wong, Erol Fikrig

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Recombinant West Nile virus envelope (E) protein was examined in enzyme-linked immunosorbent assay (ELISA) to detect antibodies elicited during West Nile virus infection. Horses (nine of 10) and humans (six of six) with confirmed West Nile virus infection had IgG and/or IgM antibodies to the E protein. Antibodies to the recombinant West Nile virus membrane and nonstructural 1 proteins were not detected in any of these sera. An E protein-based ELISA may aid in the serological diagnosis of West Nile virus infection.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalVector borne and zoonotic diseases (Larchmont, N.Y.)
Volume2
Issue number2
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases
  • Virology

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