TY - JOUR
T1 - A review of gene and stem cell therapy in cutaneous wound healing
AU - Branski, Ludwik K.
AU - Gauglitz, Gerd G.
AU - Herndon, David N.
AU - Jeschke, Marc G.
N1 - Funding Information:
We would like to express our gratitude to the Postdoctoral Training in Trauma and Burns program (#T32-GM08256), Clayton Foundation for Research, American Surgical Association Foundation, Anderson Foundation, and Shriners Hospital for Children (Grant #8660 and 8460) for their generous support. The authors also would like to acknowledge the following individuals who worked on this project over the years and without them progress would not have been possible: J. Regino Perez-Polo, PhD, Tom Woods, PhD, Robert E. Barrow, PhD, Marcus Spies, MD, Doerte Vormann, MD, Georg Richter, MD, Thomas Schubert, MD, and Markus Bolle, MD.
PY - 2009/3
Y1 - 2009/3
N2 - Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.
AB - Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.
KW - Cutaneous stem cells
KW - Growth factors
KW - Liposomes
KW - Non-viral gene therapy
KW - Umbilical cord derived stem cells
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U2 - 10.1016/j.burns.2008.03.009
DO - 10.1016/j.burns.2008.03.009
M3 - Review article
C2 - 18603379
AN - SCOPUS:58849124929
SN - 0305-4179
VL - 35
SP - 171
EP - 180
JO - Burns
JF - Burns
IS - 2
ER -