A review of gene and stem cell therapy in cutaneous wound healing

Ludwik Branski, Gerd G. Gauglitz, David Herndon, Marc G. Jeschke

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalBurns
Volume35
Issue number2
DOIs
StatePublished - Mar 2009

Fingerprint

Cell- and Tissue-Based Therapy
Wound Healing
Stem Cells
Skin
Wounds and Injuries
Genes
Gene Transfer Techniques
Adult Stem Cells
Hair Follicle
Embryonic Stem Cells
Fetal Blood
Genetic Therapy
Transfection
Adipose Tissue
Intercellular Signaling Peptides and Proteins
Therapeutics
Bone Marrow
Cytokines
Pressure
Injections

Keywords

  • Cutaneous stem cells
  • Growth factors
  • Liposomes
  • Non-viral gene therapy
  • Umbilical cord derived stem cells

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

A review of gene and stem cell therapy in cutaneous wound healing. / Branski, Ludwik; Gauglitz, Gerd G.; Herndon, David; Jeschke, Marc G.

In: Burns, Vol. 35, No. 2, 03.2009, p. 171-180.

Research output: Contribution to journalArticle

Branski, L, Gauglitz, GG, Herndon, D & Jeschke, MG 2009, 'A review of gene and stem cell therapy in cutaneous wound healing', Burns, vol. 35, no. 2, pp. 171-180. https://doi.org/10.1016/j.burns.2008.03.009
Branski, Ludwik ; Gauglitz, Gerd G. ; Herndon, David ; Jeschke, Marc G. / A review of gene and stem cell therapy in cutaneous wound healing. In: Burns. 2009 ; Vol. 35, No. 2. pp. 171-180.
@article{4f28e64a89ad4692935b0429df5adbe0,
title = "A review of gene and stem cell therapy in cutaneous wound healing",
abstract = "Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.",
keywords = "Cutaneous stem cells, Growth factors, Liposomes, Non-viral gene therapy, Umbilical cord derived stem cells",
author = "Ludwik Branski and Gauglitz, {Gerd G.} and David Herndon and Jeschke, {Marc G.}",
year = "2009",
month = "3",
doi = "10.1016/j.burns.2008.03.009",
language = "English (US)",
volume = "35",
pages = "171--180",
journal = "Burns",
issn = "0305-4179",
publisher = "Elsevier Limited",
number = "2",

}

TY - JOUR

T1 - A review of gene and stem cell therapy in cutaneous wound healing

AU - Branski, Ludwik

AU - Gauglitz, Gerd G.

AU - Herndon, David

AU - Jeschke, Marc G.

PY - 2009/3

Y1 - 2009/3

N2 - Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.

AB - Different therapies that effect wound repair have been proposed over the last few decades. This article reviews the emerging fields of gene and stem cell therapy in wound healing. Gene therapy, initially developed for treatment of congenital defects, is a new option for enhancing wound repair. In order to accelerate wound closure, genes encoding for growth factors or cytokines showed the greatest potential. The majority of gene delivery systems are based on viral transfection, naked DNA application, high pressure injection, or liposomal vectors. Embryonic and adult stem cells have a prolonged self-renewal capacity with the ability to differentiate into various tissue types. A variety of sources, such as bone marrow, peripheral blood, umbilical cord blood, adipose tissue, skin and hair follicles, have been utilized to isolate stem cells to accelerate the healing response of acute and chronic wounds. Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds.

KW - Cutaneous stem cells

KW - Growth factors

KW - Liposomes

KW - Non-viral gene therapy

KW - Umbilical cord derived stem cells

UR - http://www.scopus.com/inward/record.url?scp=58849124929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58849124929&partnerID=8YFLogxK

U2 - 10.1016/j.burns.2008.03.009

DO - 10.1016/j.burns.2008.03.009

M3 - Article

VL - 35

SP - 171

EP - 180

JO - Burns

JF - Burns

SN - 0305-4179

IS - 2

ER -