A review of oral labetalol and nifedipine in mild to moderate hypertension in pregnancy

Shannon M. Clark, Holly E. Dunn, Gary D.V. Hankins

    Research output: Contribution to journalReview articlepeer-review

    28 Scopus citations

    Abstract

    Hypertension is the most commonly encountered medical condition in pregnancy, contributing significantly to maternal and perinatal morbidity and mortality. Mild to moderate hypertension in pregnancy is defined as systolic blood pressure of 140-159 mmHg or diastolic blood pressure of 90-109 mmHg (7-9% of pregnancies). When treating hypertension in pregnancy, not only do physiologic changes of pregnancy have an effect on the pharmacokinetics and pharmacodynamics of the drugs used, but the pathophysiology of hypertensive disorders of pregnancy also have an effect. To date, evidence is lacking on the pharmacokinetics and pharmacodynamics of commonly used antihypertensive drugs, which oftentimes leads to suboptimal treatment of hypertensive pregnant women. When considering which agents to use for treatment of mild to moderate hypertension, specifically in gestational and chronic hypertension, oral labetalol and nifedipine are valid options. An overview of the profile for use, safety, and current pharmacokinetic data for each agent is presented here.

    Original languageEnglish (US)
    Pages (from-to)548-555
    Number of pages8
    JournalSeminars in Perinatology
    Volume39
    Issue number7
    DOIs
    StatePublished - Nov 2015

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Obstetrics and Gynecology

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