A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder

Robert M A Hirschfeld, Siegfried Kasper

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Bipolar disorder is a recurrent lifelong condition associated with significant morbidity and mortality. The main goals of treatment are the acute management of manic/depressive episodes and the prevention of recurrence. Mood stabilizers are the basis of most treatment regimens. Although lithium is the classical mood stabilizer, dissatisfaction with its efficacy and tolerability has led to increased use of other moodstabilizing agents, including anticonvulsants. Newer anticonvulsants such as oxcarbazepine may offer improved tolerability and fewer drug-drug interactions compared to older drugs like carbamazepine. A search of the literature shows that data from controlled clinical studies support the efficacy of carbamazepine in treating acute mania and as maintenance therapy. In addition, a growing body of data for oxcarbazepine suggests that this newer agent may have a similar efficacy profile to carbamazepine, with improved tolerability. This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)507-522
Number of pages16
JournalInternational Journal of Neuropsychopharmacology
Volume7
Issue number4
DOIs
StatePublished - Dec 2004

Fingerprint

Carbamazepine
Bipolar Disorder
Anticonvulsants
Drug Interactions
Lithium
Pharmaceutical Preparations
Morbidity
Recurrence
Mortality
oxcarbazepine
Therapeutics

Keywords

  • Acute mania
  • Bipolar disorder
  • Carbamazepine
  • Mood stabilizer
  • Oxcarbazepine

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder. / Hirschfeld, Robert M A; Kasper, Siegfried.

In: International Journal of Neuropsychopharmacology, Vol. 7, No. 4, 12.2004, p. 507-522.

Research output: Contribution to journalArticle

@article{560bc90224dd412fb6e773b8f305a611,
title = "A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder",
abstract = "Bipolar disorder is a recurrent lifelong condition associated with significant morbidity and mortality. The main goals of treatment are the acute management of manic/depressive episodes and the prevention of recurrence. Mood stabilizers are the basis of most treatment regimens. Although lithium is the classical mood stabilizer, dissatisfaction with its efficacy and tolerability has led to increased use of other moodstabilizing agents, including anticonvulsants. Newer anticonvulsants such as oxcarbazepine may offer improved tolerability and fewer drug-drug interactions compared to older drugs like carbamazepine. A search of the literature shows that data from controlled clinical studies support the efficacy of carbamazepine in treating acute mania and as maintenance therapy. In addition, a growing body of data for oxcarbazepine suggests that this newer agent may have a similar efficacy profile to carbamazepine, with improved tolerability. This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder.",
keywords = "Acute mania, Bipolar disorder, Carbamazepine, Mood stabilizer, Oxcarbazepine",
author = "Hirschfeld, {Robert M A} and Siegfried Kasper",
year = "2004",
month = "12",
doi = "10.1017/S1461145704004651",
language = "English (US)",
volume = "7",
pages = "507--522",
journal = "International Journal of Neuropsychopharmacology",
issn = "1461-1457",
publisher = "Cambridge University Press",
number = "4",

}

TY - JOUR

T1 - A review of the evidence for carbamazepine and oxcarbazepine in the treatment of bipolar disorder

AU - Hirschfeld, Robert M A

AU - Kasper, Siegfried

PY - 2004/12

Y1 - 2004/12

N2 - Bipolar disorder is a recurrent lifelong condition associated with significant morbidity and mortality. The main goals of treatment are the acute management of manic/depressive episodes and the prevention of recurrence. Mood stabilizers are the basis of most treatment regimens. Although lithium is the classical mood stabilizer, dissatisfaction with its efficacy and tolerability has led to increased use of other moodstabilizing agents, including anticonvulsants. Newer anticonvulsants such as oxcarbazepine may offer improved tolerability and fewer drug-drug interactions compared to older drugs like carbamazepine. A search of the literature shows that data from controlled clinical studies support the efficacy of carbamazepine in treating acute mania and as maintenance therapy. In addition, a growing body of data for oxcarbazepine suggests that this newer agent may have a similar efficacy profile to carbamazepine, with improved tolerability. This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder.

AB - Bipolar disorder is a recurrent lifelong condition associated with significant morbidity and mortality. The main goals of treatment are the acute management of manic/depressive episodes and the prevention of recurrence. Mood stabilizers are the basis of most treatment regimens. Although lithium is the classical mood stabilizer, dissatisfaction with its efficacy and tolerability has led to increased use of other moodstabilizing agents, including anticonvulsants. Newer anticonvulsants such as oxcarbazepine may offer improved tolerability and fewer drug-drug interactions compared to older drugs like carbamazepine. A search of the literature shows that data from controlled clinical studies support the efficacy of carbamazepine in treating acute mania and as maintenance therapy. In addition, a growing body of data for oxcarbazepine suggests that this newer agent may have a similar efficacy profile to carbamazepine, with improved tolerability. This review presents a balanced selection of the key studies on carbamazepine and oxcarbazepine in bipolar disorder.

KW - Acute mania

KW - Bipolar disorder

KW - Carbamazepine

KW - Mood stabilizer

KW - Oxcarbazepine

UR - http://www.scopus.com/inward/record.url?scp=10644278863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=10644278863&partnerID=8YFLogxK

U2 - 10.1017/S1461145704004651

DO - 10.1017/S1461145704004651

M3 - Article

VL - 7

SP - 507

EP - 522

JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

SN - 1461-1457

IS - 4

ER -