A role for calcineurin in Alzheimer's disease

Lindsay C. Reese, Giulio Taglialatela

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is an incurable age-related neurodegenerative disorder characterized by profound memory dysfunction. This bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (Aβ). Recent evidence suggests that pre-fibrillar soluble Aβ underlies an early, progressive loss of synapses that is a hallmark of AD. One of the downstream effects of soluble Aβ aggregates is the activation of the phosphatase calcineurin (CaN). This review details the evidence of CaN hyperactivity in 'normal' aging, models of AD, and actual disease pathogenesis; elaborates on how this could manifest as memory impairment, neuroinflammation, hyperphosphorylated tau, and neuronal death.

Original languageEnglish (US)
Pages (from-to)685-692
Number of pages8
JournalCurrent Neuropharmacology
Volume9
Issue number4
StatePublished - Dec 2011

Fingerprint

Calcineurin
Alzheimer Disease
Amyloid Plaques
Amyloid
Neurodegenerative Diseases
Synapses
Hippocampus
Brain

Keywords

  • Alzheimers
  • Amyloid beta
  • Calcineurin
  • Calcium

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Pharmacology
  • Neurology
  • Psychiatry and Mental health

Cite this

A role for calcineurin in Alzheimer's disease. / Reese, Lindsay C.; Taglialatela, Giulio.

In: Current Neuropharmacology, Vol. 9, No. 4, 12.2011, p. 685-692.

Research output: Contribution to journalArticle

Reese, Lindsay C. ; Taglialatela, Giulio. / A role for calcineurin in Alzheimer's disease. In: Current Neuropharmacology. 2011 ; Vol. 9, No. 4. pp. 685-692.
@article{381e67e11f194e1ab1460cf0411fecdb,
title = "A role for calcineurin in Alzheimer's disease",
abstract = "Alzheimer's disease (AD) is an incurable age-related neurodegenerative disorder characterized by profound memory dysfunction. This bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (Aβ). Recent evidence suggests that pre-fibrillar soluble Aβ underlies an early, progressive loss of synapses that is a hallmark of AD. One of the downstream effects of soluble Aβ aggregates is the activation of the phosphatase calcineurin (CaN). This review details the evidence of CaN hyperactivity in 'normal' aging, models of AD, and actual disease pathogenesis; elaborates on how this could manifest as memory impairment, neuroinflammation, hyperphosphorylated tau, and neuronal death.",
keywords = "Alzheimers, Amyloid beta, Calcineurin, Calcium",
author = "Reese, {Lindsay C.} and Giulio Taglialatela",
year = "2011",
month = "12",
language = "English (US)",
volume = "9",
pages = "685--692",
journal = "Current Neuropharmacology",
issn = "1570-159X",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - A role for calcineurin in Alzheimer's disease

AU - Reese, Lindsay C.

AU - Taglialatela, Giulio

PY - 2011/12

Y1 - 2011/12

N2 - Alzheimer's disease (AD) is an incurable age-related neurodegenerative disorder characterized by profound memory dysfunction. This bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (Aβ). Recent evidence suggests that pre-fibrillar soluble Aβ underlies an early, progressive loss of synapses that is a hallmark of AD. One of the downstream effects of soluble Aβ aggregates is the activation of the phosphatase calcineurin (CaN). This review details the evidence of CaN hyperactivity in 'normal' aging, models of AD, and actual disease pathogenesis; elaborates on how this could manifest as memory impairment, neuroinflammation, hyperphosphorylated tau, and neuronal death.

AB - Alzheimer's disease (AD) is an incurable age-related neurodegenerative disorder characterized by profound memory dysfunction. This bellwether symptom suggests involvement of the hippocampus -- a brain region responsible for memory formation -- and coincidentally an area heavily burdened by hyperphosphorylated tau and neuritic plaques of amyloid beta (Aβ). Recent evidence suggests that pre-fibrillar soluble Aβ underlies an early, progressive loss of synapses that is a hallmark of AD. One of the downstream effects of soluble Aβ aggregates is the activation of the phosphatase calcineurin (CaN). This review details the evidence of CaN hyperactivity in 'normal' aging, models of AD, and actual disease pathogenesis; elaborates on how this could manifest as memory impairment, neuroinflammation, hyperphosphorylated tau, and neuronal death.

KW - Alzheimers

KW - Amyloid beta

KW - Calcineurin

KW - Calcium

UR - http://www.scopus.com/inward/record.url?scp=82955245629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82955245629&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:82955245629

VL - 9

SP - 685

EP - 692

JO - Current Neuropharmacology

JF - Current Neuropharmacology

SN - 1570-159X

IS - 4

ER -