A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer

Christopher G. Willett, Dan G. Duda, Marek Ancukiewicz, Mira Shah, Brian G. Czito, Rex Bentley, Martin Poleski, Hiroshi Fujita, Gregory Y. Lauwers, Madeline Carroll, Douglas Tyler, Christopher Mantyh, Paul Shellito, Daniel C. Chung, Jeffrey W. Clark, Rakesh K. Jain

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Introduction. Bevacizumab is increasingly being tested with neoadjuvant regimens in patients with localized cancer, but its effects on metastasis and survival remain unknown. This study examines the long-term outcome of clinical stage II/III rectal cancer patients treated in a prospective phase II study of bevacizumab with chemoradiation and surgery. As a benchmark, we used data from an analysis of 42 patients with locally advanced rectal cancer treated with a contemporary approach of preoperative fluoropyrimidine-based radiation therapy. Materials and Methods. Outcome analyses were performed on 32 patients treated prospectively with neoadjuvant bevacizumab, 5-fluorouracil, radiation therapy, and surgery as well as 42 patients treated with standard fluoropyrimidine-based chemoradiation. Results. Overall survival, disease-free survival, and local control showed favorable trends in patients treated with bevacizumab with chemoradiation followed by surgery. Acute and postoperative toxicity appeared acceptable.

Original languageEnglish (US)
Pages (from-to)845-851
Number of pages7
JournalOncologist
Volume15
Issue number8
DOIs
StatePublished - 2010
Externally publishedYes

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Keywords

  • Bevacizumab
  • Chemoradiation
  • Neoadjuvant
  • Rectal cancer
  • Toxicity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Willett, C. G., Duda, D. G., Ancukiewicz, M., Shah, M., Czito, B. G., Bentley, R., Poleski, M., Fujita, H., Lauwers, G. Y., Carroll, M., Tyler, D., Mantyh, C., Shellito, P., Chung, D. C., Clark, J. W., & Jain, R. K. (2010). A safety and survival analysis of neoadjuvant bevacizumab with standard chemoradiation in a phase I/II study compared with standard chemoradiation in locally advanced rectal cancer. Oncologist, 15(8), 845-851. https://doi.org/10.1634/theoncologist.2010-0030