A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia

Yin J. Chen, Georg Deutsch, Ramadass Satya, Hong Gang Liu, James M. Mountz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalComputerized Medical Imaging and Graphics
Volume37
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Vascular Dementia
Brain Diseases
Single-Photon Emission-Computed Tomography
Brain
Cerebrovascular Circulation
Alzheimer Disease
Regional Blood Flow
Blood
Technetium Tc 99m Exametazime
Parietal Lobe
Flow patterns
Magnetic resonance imaging
Dementia
White Matter

Keywords

  • Alzheimer's disease
  • Brain
  • Circumferential profile
  • SPECT
  • Tc-99m HMPAO
  • Vascular dementia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health Informatics
  • Radiological and Ultrasound Technology
  • Computer Graphics and Computer-Aided Design
  • Computer Vision and Pattern Recognition

Cite this

A semi-quantitative method for correlating brain disease groups with normal controls using SPECT : Alzheimer's disease versus vascular dementia. / Chen, Yin J.; Deutsch, Georg; Satya, Ramadass; Liu, Hong Gang; Mountz, James M.

In: Computerized Medical Imaging and Graphics, Vol. 37, No. 1, 01.2013, p. 40-47.

Research output: Contribution to journalArticle

Chen, Yin J. ; Deutsch, Georg ; Satya, Ramadass ; Liu, Hong Gang ; Mountz, James M. / A semi-quantitative method for correlating brain disease groups with normal controls using SPECT : Alzheimer's disease versus vascular dementia. In: Computerized Medical Imaging and Graphics. 2013 ; Vol. 37, No. 1. pp. 40-47.
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