A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia

Yin J. Chen, Georg Deutsch, Ramadass Satya, Hong Gang Liu, James M. Mountz

Research output: Contribution to journalArticle

18 Scopus citations


Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalComputerized Medical Imaging and Graphics
Issue number1
StatePublished - Jan 1 2013



  • Alzheimer's disease
  • Brain
  • Circumferential profile
  • Tc-99m HMPAO
  • Vascular dementia

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design

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