A semi-quantitative method for correlating brain disease groups with normal controls using SPECT

Alzheimer's disease versus vascular dementia

Yin J. Chen, Georg Deutsch, Ramadass Satya, Hong Gang Liu, James M. Mountz

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalComputerized Medical Imaging and Graphics
Volume37
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

Vascular Dementia
Brain Diseases
Single-Photon Emission-Computed Tomography
Brain
Cerebrovascular Circulation
Alzheimer Disease
Regional Blood Flow
Blood
Technetium Tc 99m Exametazime
Parietal Lobe
Flow patterns
Magnetic resonance imaging
Dementia
White Matter

Keywords

  • Alzheimer's disease
  • Brain
  • Circumferential profile
  • SPECT
  • Tc-99m HMPAO
  • Vascular dementia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Health Informatics
  • Radiological and Ultrasound Technology
  • Computer Graphics and Computer-Aided Design
  • Computer Vision and Pattern Recognition

Cite this

A semi-quantitative method for correlating brain disease groups with normal controls using SPECT : Alzheimer's disease versus vascular dementia. / Chen, Yin J.; Deutsch, Georg; Satya, Ramadass; Liu, Hong Gang; Mountz, James M.

In: Computerized Medical Imaging and Graphics, Vol. 37, No. 1, 01.2013, p. 40-47.

Research output: Contribution to journalArticle

Chen, Yin J. ; Deutsch, Georg ; Satya, Ramadass ; Liu, Hong Gang ; Mountz, James M. / A semi-quantitative method for correlating brain disease groups with normal controls using SPECT : Alzheimer's disease versus vascular dementia. In: Computerized Medical Imaging and Graphics. 2013 ; Vol. 37, No. 1. pp. 40-47.
@article{f5eb4c1e84894afd8283b1829c8a468f,
title = "A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia",
abstract = "Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.",
keywords = "Alzheimer's disease, Brain, Circumferential profile, SPECT, Tc-99m HMPAO, Vascular dementia",
author = "Chen, {Yin J.} and Georg Deutsch and Ramadass Satya and Liu, {Hong Gang} and Mountz, {James M.}",
year = "2013",
month = "1",
doi = "10.1016/j.compmedimag.2012.11.001",
language = "English (US)",
volume = "37",
pages = "40--47",
journal = "Computerized Medical Imaging and Graphics",
issn = "0895-6111",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - A semi-quantitative method for correlating brain disease groups with normal controls using SPECT

T2 - Alzheimer's disease versus vascular dementia

AU - Chen, Yin J.

AU - Deutsch, Georg

AU - Satya, Ramadass

AU - Liu, Hong Gang

AU - Mountz, James M.

PY - 2013/1

Y1 - 2013/1

N2 - Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

AB - Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

KW - Alzheimer's disease

KW - Brain

KW - Circumferential profile

KW - SPECT

KW - Tc-99m HMPAO

KW - Vascular dementia

UR - http://www.scopus.com/inward/record.url?scp=84875369690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875369690&partnerID=8YFLogxK

U2 - 10.1016/j.compmedimag.2012.11.001

DO - 10.1016/j.compmedimag.2012.11.001

M3 - Article

VL - 37

SP - 40

EP - 47

JO - Computerized Medical Imaging and Graphics

JF - Computerized Medical Imaging and Graphics

SN - 0895-6111

IS - 1

ER -