A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia

Yin J. Chen; Georg Deutsch; Ramadass Satya; Hong Gang Liu; James M. Mountz

doi:10.1016/j.compmedimag.2012.11.001

A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia

Yin J. Chen, Georg Deutsch, Ramadass Satya, Hong Gang Liu, James M. Mountz

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

Original language	English (US)
Pages (from-to)	40-47
Number of pages	8
Journal	Computerized Medical Imaging and Graphics
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.compmedimag.2012.11.001
State	Published - Jan 2013
Externally published	Yes

Keywords

Alzheimer's disease
Brain
Circumferential profile
SPECT
Tc-99m HMPAO
Vascular dementia

ASJC Scopus subject areas

Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Computer Vision and Pattern Recognition
Health Informatics
Computer Graphics and Computer-Aided Design

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10.1016/j.compmedimag.2012.11.001

Cite this

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title = "A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia",

abstract = "Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.",

keywords = "Alzheimer's disease, Brain, Circumferential profile, SPECT, Tc-99m HMPAO, Vascular dementia",

author = "Chen, {Yin J.} and Georg Deutsch and Ramadass Satya and Liu, {Hong Gang} and Mountz, {James M.}",

note = "Funding Information: This work was supported in part by the UAB Health Services Foundation-General Endowment Fund [grant number 200702 ] to GD, and this grant funding sponsor had no direct role in the research and manuscript submission process. For the remaining authors none were declared. ",

year = "2013",

month = jan,

doi = "10.1016/j.compmedimag.2012.11.001",

language = "English (US)",

volume = "37",

pages = "40--47",

journal = "Computerized Medical Imaging and Graphics",

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T1 - A semi-quantitative method for correlating brain disease groups with normal controls using SPECT

T2 - Alzheimer's disease versus vascular dementia

AU - Chen, Yin J.

AU - Deutsch, Georg

AU - Satya, Ramadass

AU - Liu, Hong Gang

AU - Mountz, James M.

N1 - Funding Information: This work was supported in part by the UAB Health Services Foundation-General Endowment Fund [grant number 200702 ] to GD, and this grant funding sponsor had no direct role in the research and manuscript submission process. For the remaining authors none were declared.

PY - 2013/1

Y1 - 2013/1

N2 - Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

AB - Purpose: To demonstrate the utility of semi-quantitative circumferential-profile analysis of regional cerebral blood flow (rCBF) SPECT in Alzheimer's disease (AD) versus white matter vascular dementia (WM-VaD). Methods: Subjects underwent dementia evaluation, MRI and Tc-99m HMPAO SPECT. rCBF patterns from 11 AD and 20 WM-VaD patients were compared to 17 controls using semi-quantitative circumferential-profile analysis. Results: AD patients showed more significant semi-quantitative circumferential-profile reductions in the posterior temporo-parietal regions, whereas WM-VaD patients demonstrated greater reductions involving the frontal regions of the brain. Conclusion: Semi-quantitative circumferential-profile analysis provides a practical semi-quantitative method to evaluate brain SPECT scans in AD versus WM-VaD patients.

KW - Alzheimer's disease

KW - Brain

KW - Circumferential profile

KW - SPECT

KW - Tc-99m HMPAO

KW - Vascular dementia

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A semi-quantitative method for correlating brain disease groups with normal controls using SPECT: Alzheimer's disease versus vascular dementia

Abstract

Keywords

ASJC Scopus subject areas

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