A serological survey of ebola virus infection in central African nonhuman primates

Eric M. Leroy, P. Telfer, B. Kumulungui, P. Yaba, P. Rouquet, P. Roques, J. P. Gonzalez, Thomas Ksiazek, P. E. Rollin, E. Nerrienet

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

We used an ELISA to determine the prevalence of IgG antibodies specific for the Zaire subtype of Ebola virus in 790 nonhuman primates, belonging to 20 species, studied between 1985 and 2000 in Cameroon, Gabon, and the Republic of Congo. The seroprevalence rate of Ebola antibody in wild-born chimpanzees was 12.9%, indicating that (1) Ebola virus circulates in the forests of a large region of central Africa, including countries such as Cameroon, where no human cases of Ebola infections have been reported; (2) Ebola virus was present in the area before recent outbreaks in humans; (3) chimpanzees are continuously in contact with the virus; and (4) nonlethal Ebola infection can occur in chimpanzees. These results, together with the unexpected detection of Ebola-specific IgG in other species (5 drills, 1 baboon, 1 mandrill, and 1 Cercopithecus), may help to narrow the search for the reservoir of Ebola virus. They also suggest that future Ebola outbreaks may occur anywhere in the central African forest region.

Original languageEnglish (US)
Pages (from-to)1895-1899
Number of pages5
JournalJournal of Infectious Diseases
Volume190
Issue number11
DOIs
StatePublished - Dec 1 2004
Externally publishedYes

Fingerprint

Ebola Hemorrhagic Fever
Ebolavirus
Primates
Pan troglodytes
Cameroon
Mandrillus
Disease Outbreaks
Cercopithecus
Immunoglobulin G
Gabon
Congo
Central Africa
Antibodies
Papio
Seroepidemiologic Studies
Enzyme-Linked Immunosorbent Assay
Viruses
Surveys and Questionnaires

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Leroy, E. M., Telfer, P., Kumulungui, B., Yaba, P., Rouquet, P., Roques, P., ... Nerrienet, E. (2004). A serological survey of ebola virus infection in central African nonhuman primates. Journal of Infectious Diseases, 190(11), 1895-1899. https://doi.org/10.1086/425421

A serological survey of ebola virus infection in central African nonhuman primates. / Leroy, Eric M.; Telfer, P.; Kumulungui, B.; Yaba, P.; Rouquet, P.; Roques, P.; Gonzalez, J. P.; Ksiazek, Thomas; Rollin, P. E.; Nerrienet, E.

In: Journal of Infectious Diseases, Vol. 190, No. 11, 01.12.2004, p. 1895-1899.

Research output: Contribution to journalArticle

Leroy, EM, Telfer, P, Kumulungui, B, Yaba, P, Rouquet, P, Roques, P, Gonzalez, JP, Ksiazek, T, Rollin, PE & Nerrienet, E 2004, 'A serological survey of ebola virus infection in central African nonhuman primates', Journal of Infectious Diseases, vol. 190, no. 11, pp. 1895-1899. https://doi.org/10.1086/425421
Leroy EM, Telfer P, Kumulungui B, Yaba P, Rouquet P, Roques P et al. A serological survey of ebola virus infection in central African nonhuman primates. Journal of Infectious Diseases. 2004 Dec 1;190(11):1895-1899. https://doi.org/10.1086/425421
Leroy, Eric M. ; Telfer, P. ; Kumulungui, B. ; Yaba, P. ; Rouquet, P. ; Roques, P. ; Gonzalez, J. P. ; Ksiazek, Thomas ; Rollin, P. E. ; Nerrienet, E. / A serological survey of ebola virus infection in central African nonhuman primates. In: Journal of Infectious Diseases. 2004 ; Vol. 190, No. 11. pp. 1895-1899.
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