A simple, efficient procedure for the synthesis of some amino acid linked ureido phosphoramidate derivatives

Ru Yu Chen, Jia Zhou

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

N′,N′-bis(2-chloroethyl)-O-aryl-N3-ethoxycarbonyl substituted methylene ureido phosphoramidates (2) designed as promising antivirus and antitumor agents have been synthesized in excellent yields via the corresponding thiourea derivatives (1) involving a homogeneous desulphurisation reaction as the key step and the possible mechanism is proposed herein. The stability and cleavage of acid-catalyzed hydrolysis of 2 are also discussed.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalChinese Chemical Letters
Volume7
Issue number6
StatePublished - Dec 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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