A simple, efficient procedure for the synthesis of some amino acid linked ureido phosphoramidate derivatives

Ru Yu Chen, Jia Zhou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

N′,N′-bis(2-chloroethyl)-O-aryl-N3-ethoxycarbonyl substituted methylene ureido phosphoramidates (2) designed as promising antivirus and antitumor agents have been synthesized in excellent yields via the corresponding thiourea derivatives (1) involving a homogeneous desulphurisation reaction as the key step and the possible mechanism is proposed herein. The stability and cleavage of acid-catalyzed hydrolysis of 2 are also discussed.

Original languageEnglish (US)
Pages (from-to)539-542
Number of pages4
JournalChinese Chemical Letters
Volume7
Issue number6
StatePublished - 1996
Externally publishedYes

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Thiourea
Antineoplastic Agents
Hydrolysis
Derivatives
Amino Acids
Acids
phosphoramidic acid

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

A simple, efficient procedure for the synthesis of some amino acid linked ureido phosphoramidate derivatives. / Chen, Ru Yu; Zhou, Jia.

In: Chinese Chemical Letters, Vol. 7, No. 6, 1996, p. 539-542.

Research output: Contribution to journalArticle

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