N′,N′-bis(2-chloroethyl)-O-aryl-N3-ethoxycarbonyl substituted methylene ureido phosphoramidates (2) designed as promising antivirus and antitumor agents have been synthesized in excellent yields via the corresponding thiourea derivatives (1) involving a homogeneous desulphurisation reaction as the key step and the possible mechanism is proposed herein. The stability and cleavage of acid-catalyzed hydrolysis of 2 are also discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Chinese Chemical Letters|
|State||Published - Dec 1 1996|
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