A simple, reproducible technique for establishing leptomeningeal tumors in nude rats

Kristin H. Janczewski, Claudia L. Chalk, Richard Pyles, Linda M. Parysek, Lawrence W. Unger, Ronald E. Warnick

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The incidence of leptomeningeal carcinomatosis is on the rise and current treatment modalities have limited efficacy. The development of new treatment strategies has been hampered by the lack of an appropriate animal model that accurately parallels the clinical condition. We have developed a new surgical technique for the establishment of leptomeningeal tumors in rats. Our technique is simple, reproducible and associated with low morbidity and mortality. Tumor implantation resulted in a defined neurological endpoint and a reproducible time course of disease progression using both human medulloblastoma and breast carcinoma cell lines. This animal model provides an appropriate system for testing conventional and new biologic therapies in both early and late stages of leptomeningeal disease.

Original languageEnglish (US)
Pages (from-to)45-49
Number of pages5
JournalJournal of Neuroscience Methods
Volume85
Issue number1
DOIs
StatePublished - Nov 1 1998
Externally publishedYes

Fingerprint

Nude Rats
Animal Models
Meningeal Carcinomatosis
Biological Therapy
Medulloblastoma
Disease Progression
Neoplasms
Breast Neoplasms
Morbidity
Cell Line
Mortality
Incidence
Therapeutics

Keywords

  • Breast neoplasms
  • Carcinomatosis
  • Catheterization
  • Medulloblastoma
  • Nude
  • Rats

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A simple, reproducible technique for establishing leptomeningeal tumors in nude rats. / H. Janczewski, Kristin; L. Chalk, Claudia; Pyles, Richard; M. Parysek, Linda; W. Unger, Lawrence; E. Warnick, Ronald.

In: Journal of Neuroscience Methods, Vol. 85, No. 1, 01.11.1998, p. 45-49.

Research output: Contribution to journalArticle

H. Janczewski, Kristin ; L. Chalk, Claudia ; Pyles, Richard ; M. Parysek, Linda ; W. Unger, Lawrence ; E. Warnick, Ronald. / A simple, reproducible technique for establishing leptomeningeal tumors in nude rats. In: Journal of Neuroscience Methods. 1998 ; Vol. 85, No. 1. pp. 45-49.
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