A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

Keyphrases

• West Nile Virus 100%
• NS4B 100%
• Single Amino Acid Substitution 100%
• NS4A 100%
• Flavivirus Inhibitors 100%
• Lycorine 100%
• Flavivirus 28%
• Viral RNA Replication 28%
• Alphavirus 14%
• Cell Culture 14%
• Yellow Fever 14%
• RNA Synthesis 14%
• Antiviral Activity 14%
• Viral 14%
• Viral Titer 14%
• Cytotoxicity 14%
• Dengue Fever 14%
• West Nile 14%
• NS4B Inhibitors 14%
• Vesicular Stomatitis Virus 14%
• Hydroxyl Group 14%
• Rhabdovirus 14%
• Endoplasmic Reticulum 14%
• Western Equine Encephalitis Virus 14%
• Amino Acid Position 14%
• Antiviral Development 14%
• Compound Potency 14%
• Chemistry Synthesis 14%

Immunology and Microbiology

• West Nile Virus 100%
• Flavivirus 100%
• Amino Acid Substitution 100%
• NS4B 100%
• NS4A 100%
• RNA Replication 50%
• Alphavirus 25%
• RNA Synthesis 25%
• Cell Culture 25%
• Cytotoxicity 25%
• Antiviral Activity 25%
• Yellow Fever Virus 25%
• Viral Load 25%
• Dengue Virus 25%
• Vesiculovirus 25%
• Rhabdoviridae 25%
• Western Equine Encephalitis Virus 25%
• Endoplasmic Reticulum Membrane 25%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• West Nile Virus 100%
• Flavivirus 100%
• Lycorine 100%
• Antivirus Agent 28%
• Virus RNA 28%
• Cell Culture 14%
• Antiviral Activity 14%
• Alphavirus 14%
• Yellow Fever Virus 14%
• Dengue Virus 14%
• Vesiculovirus 14%
• Hydroxyl Group 14%
• Rhabdoviridae 14%
• Western Equine Encephalitis Virus 14%
• Nonstructural Protein 4B 14%
• Nonstructural Protein 4A 14%
• Cytotoxicity 14%