A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men

Yiannis E. Tsekouras, Faidon Magkos, Konstantinos I. Prentzas, Konstantinos N. Basioukas, Stergoula G. Matsama, Amalia E. Yanni, Stavros A. Kavouras, Labros S. Sidossis

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A single bout of prolonged aerobic exercise lowers plasma TAG (triacylglycerol) concentrations the next day by increasing the efficiency of VLDL (very-low-density lipoprotein)-TAG removal from the circulation. The effect of resistance exercise on VLDL-TAG metabolism is not known. Therefore we evaluated VLDL-TAG kinetics by using stable isotope-labelled tracers in eight healthy untrained men (age, 25.3 ± 0.8 years; body mass index, 24.5 ± 0.6 kg/m2) in the post-absorptive state in the morning on two separate occasions: once after performing a single 90-min bout of strenuous isokinetic resistance exercise (three sets × ten repetitions, 12 exercises at 80% of maximum peak torque production, with a 2-min rest interval between exercises) on the preceding afternoon and once after an equivalent period of rest. Fasting plasma VLDL-TAG concentrations in the morning after exercise were significantly lower than in the morning after rest (0.23 ± 0.04 compared with 0.33 ± 0.06 mmol/l respectively; P = 0.001). Hepatic VLDL-TAG secretion rate was not different (P = 0.31), but plasma clearance rate of VLDL-TAG was significantly higher (by 26 ± 8%) after exercise than rest (31 ± 3 compared with 25 ± 3 ml/min respectively; P = 0.004), and the mean residence time of VLDL-TAG in the circulation was significantly shorter (113 ± 10 compared with 144 ± 18 min respectively; P = 0.02). Fasting plasma NEFA (non-esterified fatty acid; 'free' fatty acid) and serum β-hydroxybutyrate concentrations were both significantly higher after exercise than rest (P < 0.05), whereas plasma glucose and serum insulin concentrations were not different (P > 0.30). We conclude that, in healthy untrained men, a single bout of whole-body resistance exercise lowers fasting plasma VLDL-TAG concentrations by augmenting VLDL-TAG removal from plasma. The effect appears to be qualitatively and quantitatively similar to that reported previously for aerobic exercise.

Original languageEnglish (US)
Pages (from-to)147-156
Number of pages10
JournalClinical Science
Volume116
Issue number2
DOIs
StatePublished - Jan 2009
Externally publishedYes

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VLDL Lipoproteins
Triglycerides
Exercise
Fasting
Nonesterified Fatty Acids
Hydroxybutyrates
Torque
Isotopes
Body Mass Index
Fatty Acids

Keywords

  • Acute exercise
  • Hepatic metabolism
  • Lipid kinetics
  • Triacylglycerol
  • Very-low-density lipoprotein (VLDL)

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tsekouras, Y. E., Magkos, F., Prentzas, K. I., Basioukas, K. N., Matsama, S. G., Yanni, A. E., ... Sidossis, L. S. (2009). A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men. Clinical Science, 116(2), 147-156. https://doi.org/10.1042/CS20080078

A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men. / Tsekouras, Yiannis E.; Magkos, Faidon; Prentzas, Konstantinos I.; Basioukas, Konstantinos N.; Matsama, Stergoula G.; Yanni, Amalia E.; Kavouras, Stavros A.; Sidossis, Labros S.

In: Clinical Science, Vol. 116, No. 2, 01.2009, p. 147-156.

Research output: Contribution to journalArticle

Tsekouras, YE, Magkos, F, Prentzas, KI, Basioukas, KN, Matsama, SG, Yanni, AE, Kavouras, SA & Sidossis, LS 2009, 'A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men', Clinical Science, vol. 116, no. 2, pp. 147-156. https://doi.org/10.1042/CS20080078
Tsekouras, Yiannis E. ; Magkos, Faidon ; Prentzas, Konstantinos I. ; Basioukas, Konstantinos N. ; Matsama, Stergoula G. ; Yanni, Amalia E. ; Kavouras, Stavros A. ; Sidossis, Labros S. / A single bout of whole-body resistance exercise augments basal VLDL-triacylglycerol removal from plasma in healthy untrained men. In: Clinical Science. 2009 ; Vol. 116, No. 2. pp. 147-156.
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