A single mutation in human mitochondrial DNA polymerase Pol γA affects both polymerization and proofreading activities of only the holoenzyme

Keyphrases

• Accessory Subunit 16%
• Active Sites 16%
• Catalytic Subunit 8%
• Common Cause 8%
• Disease Symptoms 8%
• DNA Polymerase 8%
• DNA Synthesis 8%
• Exonuclease 8%
• Exonuclease Activity 8%
• Holoenzyme 100%
• Human Mitochondrial Disease 8%
• Human Mitochondrial DNA 100%
• Mitochondria 8%
• Mitochondrial DNA Polymerase 100%
• Mitochondrium 8%
• Muscular Diseases 8%
• Neurological Disorders 8%
• Polymerase 100%
• Polymerization Activity 100%
• Proofreading Activity 100%
• Regulatory Function 8%
• Single-point mutation 100%

Biochemistry, Genetics and Molecular Biology

• Active Site 16%
• DNA Polymerase 100%
• DNA Synthesis 8%
• Enzyme Active Site 8%
• Exonuclease 16%
• Mitochondrial Disease 8%
• Mitochondrial DNA 100%
• Mitochondrion 8%
• Polymerase 100%