A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Chad E. Mire; Joan B. Geisbert; Krista M. Versteeg; Natalia Mamaeva; Krystle N. Agans; Thomas W. Geisbert; John H. Connor

doi:10.1093/infdis/jiv126

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Chad E. Mire, Joan B. Geisbert, Krista M. Versteeg, Natalia Mamaeva, Krystle N. Agans, Thomas W. Geisbert, John H. Connor

Microbiology And Immunology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

Original language	English (US)
Pages (from-to)	S384-S388
Journal	Journal of Infectious Diseases
Volume	212
DOIs	https://doi.org/10.1093/infdis/jiv126
State	Published - Oct 1 2015

Keywords

Ebola virus
Guinea pig
Marburg virus
cross-protection
filovirus
trivalent
vaccine
vesicular stomatitis virus

ASJC Scopus subject areas

General Medicine

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10.1093/infdis/jiv126

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title = "A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs",

abstract = "The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.",

keywords = "Ebola virus, Guinea pig, Marburg virus, cross-protection, filovirus, trivalent, vaccine, vesicular stomatitis virus",

author = "Mire, {Chad E.} and Geisbert, {Joan B.} and Versteeg, {Krista M.} and Natalia Mamaeva and Agans, {Krystle N.} and Geisbert, {Thomas W.} and Connor, {John H.}",

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doi = "10.1093/infdis/jiv126",

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AU - Mire, Chad E.

AU - Geisbert, Joan B.

AU - Versteeg, Krista M.

AU - Mamaeva, Natalia

AU - Agans, Krystle N.

AU - Geisbert, Thomas W.

AU - Connor, John H.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

AB - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

KW - Ebola virus

KW - Guinea pig

KW - Marburg virus

KW - cross-protection

KW - filovirus

KW - trivalent

KW - vaccine

KW - vesicular stomatitis virus

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JF - Journal of Infectious Diseases

ER -

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs

Abstract

Keywords

ASJC Scopus subject areas

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