Abstract
The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S384-S388 |
| Journal | Journal of Infectious Diseases |
| Volume | 212 |
| DOIs | |
| State | Published - Oct 1 2015 |
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Keywords
- cross-protection
- Ebola virus
- filovirus
- Guinea pig
- Marburg virus
- trivalent
- vaccine
- vesicular stomatitis virus
ASJC Scopus subject areas
- Infectious Diseases
- Immunology and Allergy
Cite this
A Single-Vector, Single-Injection Trivalent Filovirus Vaccine : Proof of Concept Study in Outbred Guinea Pigs. / Mire, Chad; Geisbert, Joan B.; Versteeg, Krista M.; Mamaeva, Natalia; Agans, Krystle N.; Geisbert, Thomas; Connor, John H.
In: Journal of Infectious Diseases, Vol. 212, 01.10.2015, p. S384-S388.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Single-Vector, Single-Injection Trivalent Filovirus Vaccine
T2 - Proof of Concept Study in Outbred Guinea Pigs
AU - Mire, Chad
AU - Geisbert, Joan B.
AU - Versteeg, Krista M.
AU - Mamaeva, Natalia
AU - Agans, Krystle N.
AU - Geisbert, Thomas
AU - Connor, John H.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.
AB - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.
KW - cross-protection
KW - Ebola virus
KW - filovirus
KW - Guinea pig
KW - Marburg virus
KW - trivalent
KW - vaccine
KW - vesicular stomatitis virus
UR - http://www.scopus.com/inward/record.url?scp=84943223963&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84943223963&partnerID=8YFLogxK
U2 - 10.1093/infdis/jiv126
DO - 10.1093/infdis/jiv126
M3 - Article
C2 - 25957964
AN - SCOPUS:84943223963
VL - 212
SP - S384-S388
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
ER -