A Single-Vector, Single-Injection Trivalent Filovirus Vaccine

Proof of Concept Study in Outbred Guinea Pigs

Chad Mire, Joan B. Geisbert, Krista M. Versteeg, Natalia Mamaeva, Krystle N. Agans, Thomas Geisbert, John H. Connor

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

Original languageEnglish (US)
Pages (from-to)S384-S388
JournalJournal of Infectious Diseases
Volume212
DOIs
StatePublished - Oct 1 2015

Fingerprint

Ebolavirus
Guinea Pigs
Marburgvirus
Vaccines
Democratic Republic of the Congo
Injections
Sudan
Vesicular Stomatitis
Primates
Glycoproteins
Viruses
Rodentia
Fever

Keywords

  • cross-protection
  • Ebola virus
  • filovirus
  • Guinea pig
  • Marburg virus
  • trivalent
  • vaccine
  • vesicular stomatitis virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy

Cite this

A Single-Vector, Single-Injection Trivalent Filovirus Vaccine : Proof of Concept Study in Outbred Guinea Pigs. / Mire, Chad; Geisbert, Joan B.; Versteeg, Krista M.; Mamaeva, Natalia; Agans, Krystle N.; Geisbert, Thomas; Connor, John H.

In: Journal of Infectious Diseases, Vol. 212, 01.10.2015, p. S384-S388.

Research output: Contribution to journalArticle

Mire, Chad ; Geisbert, Joan B. ; Versteeg, Krista M. ; Mamaeva, Natalia ; Agans, Krystle N. ; Geisbert, Thomas ; Connor, John H. / A Single-Vector, Single-Injection Trivalent Filovirus Vaccine : Proof of Concept Study in Outbred Guinea Pigs. In: Journal of Infectious Diseases. 2015 ; Vol. 212. pp. S384-S388.
@article{e544bb3edcdd454ca06343d3941f4a54,
title = "A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs",
abstract = "The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100{\%} efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.",
keywords = "cross-protection, Ebola virus, filovirus, Guinea pig, Marburg virus, trivalent, vaccine, vesicular stomatitis virus",
author = "Chad Mire and Geisbert, {Joan B.} and Versteeg, {Krista M.} and Natalia Mamaeva and Agans, {Krystle N.} and Thomas Geisbert and Connor, {John H.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1093/infdis/jiv126",
language = "English (US)",
volume = "212",
pages = "S384--S388",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",

}

TY - JOUR

T1 - A Single-Vector, Single-Injection Trivalent Filovirus Vaccine

T2 - Proof of Concept Study in Outbred Guinea Pigs

AU - Mire, Chad

AU - Geisbert, Joan B.

AU - Versteeg, Krista M.

AU - Mamaeva, Natalia

AU - Agans, Krystle N.

AU - Geisbert, Thomas

AU - Connor, John H.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

AB - The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley Guinea pigs where we observed protection from effects of all 3 filoviruses.

KW - cross-protection

KW - Ebola virus

KW - filovirus

KW - Guinea pig

KW - Marburg virus

KW - trivalent

KW - vaccine

KW - vesicular stomatitis virus

UR - http://www.scopus.com/inward/record.url?scp=84943223963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943223963&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiv126

DO - 10.1093/infdis/jiv126

M3 - Article

VL - 212

SP - S384-S388

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

ER -