A sorting signal suppresses IFITM1 restriction of viral entry

Kun Li, Rui Jia, Minghua Li, Yi Min Zheng, Chunhui Miao, Yunfang Yao, Hong Long Ji, Yunqi Geng, Wentao Qiao, Lorraine M. Albritton, Chen Liang, Shan Lu Liu

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.

Original languageEnglish (US)
Pages (from-to)4248-4259
Number of pages12
JournalJournal of Biological Chemistry
Issue number7
StatePublished - Feb 13 2015
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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