Abstract
Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4248-4259 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 290 |
| Issue number | 7 |
| DOIs | |
| State | Published - Feb 13 2015 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Fingerprint
Dive into the research topics of 'A sorting signal suppresses IFITM1 restriction of viral entry'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS