A sorting signal suppresses IFITM1 restriction of viral entry

Kun Li; Rui Jia; Minghua Li; Yi Min Zheng; Chunhui Miao; Yunfang Yao; Hong Long Ji; Yunqi Geng; Wentao Qiao; Lorraine M. Albritton; Chen Liang; Shan Lu Liu

doi:10.1074/jbc.M114.630780

A sorting signal suppresses IFITM1 restriction of viral entry

Kun Li, Rui Jia, Minghua Li, Yi Min Zheng, Chunhui Miao, Yunfang Yao, Hong Long Ji, Yunqi Geng, Wentao Qiao, Lorraine M. Albritton, Chen Liang, Shan Lu Liu

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.

Original language	English (US)
Pages (from-to)	4248-4259
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	290
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M114.630780
State	Published - Feb 13 2015
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M114.630780

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title = "A sorting signal suppresses IFITM1 restriction of viral entry",

abstract = "Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.",

author = "Kun Li and Rui Jia and Minghua Li and Zheng, \{Yi Min\} and Chunhui Miao and Yunfang Yao and Ji, \{Hong Long\} and Yunqi Geng and Wentao Qiao and Albritton, \{Lorraine M.\} and Chen Liang and Liu, \{Shan Lu\}",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.",

year = "2015",

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doi = "10.1074/jbc.M114.630780",

language = "English (US)",

volume = "290",

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TY - JOUR

T1 - A sorting signal suppresses IFITM1 restriction of viral entry

AU - Li, Kun

AU - Jia, Rui

AU - Li, Minghua

AU - Zheng, Yi Min

AU - Miao, Chunhui

AU - Yao, Yunfang

AU - Ji, Hong Long

AU - Geng, Yunqi

AU - Qiao, Wentao

AU - Albritton, Lorraine M.

AU - Liang, Chen

AU - Liu, Shan Lu

PY - 2015/2/13

Y1 - 2015/2/13

N2 - Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.

AB - Background: IFITM1 differentially inhibits viral entry. Results: IFITM1 associates with AP-3; mutation of the C-terminal KRXX motif of IFITM1 results in loss of AP-3 interaction yet increases viral entry. Conclusion: KRXX is a potential sorting motif targeting IFITM1 to lysosome. Significance: Our results provide new insight into the mechanism of IFITM1 restriction of viral infection.

UR - https://www.scopus.com/pages/publications/84922791416

UR - https://www.scopus.com/inward/citedby.url?scp=84922791416&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.630780

DO - 10.1074/jbc.M114.630780

M3 - Article

C2 - 25527505

AN - SCOPUS:84922791416

SN - 0021-9258

VL - 290

SP - 4248

EP - 4259

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

A sorting signal suppresses IFITM1 restriction of viral entry

Abstract

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