A study to evaluate the use of extended release divalproex

Michael Stone, Robert M A Hirschfeld

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS: The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS: Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS: This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalInternational Journal of Psychiatry in Clinical Practice
Volume8
Issue number3
DOIs
StatePublished - Sep 2004

Fingerprint

Valproic Acid
Psychiatry
Outpatients
Pharmacokinetics
Safety
Population

Keywords

  • Bipolar
  • Divalproex
  • Outpatient
  • Schizoaffective

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

A study to evaluate the use of extended release divalproex. / Stone, Michael; Hirschfeld, Robert M A.

In: International Journal of Psychiatry in Clinical Practice, Vol. 8, No. 3, 09.2004, p. 169-171.

Research output: Contribution to journalArticle

@article{76460904bb0e4f68b5cd6df874d62d77,
title = "A study to evaluate the use of extended release divalproex",
abstract = "BACKGROUND: Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS: The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS: Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS: This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.",
keywords = "Bipolar, Divalproex, Outpatient, Schizoaffective",
author = "Michael Stone and Hirschfeld, {Robert M A}",
year = "2004",
month = "9",
doi = "10.1080/13651500410000888",
language = "English (US)",
volume = "8",
pages = "169--171",
journal = "International Journal of Psychiatry in Clinical Practice",
issn = "1365-1501",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - A study to evaluate the use of extended release divalproex

AU - Stone, Michael

AU - Hirschfeld, Robert M A

PY - 2004/9

Y1 - 2004/9

N2 - BACKGROUND: Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS: The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS: Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS: This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.

AB - BACKGROUND: Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS: The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS: Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS: This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.

KW - Bipolar

KW - Divalproex

KW - Outpatient

KW - Schizoaffective

UR - http://www.scopus.com/inward/record.url?scp=6044228064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=6044228064&partnerID=8YFLogxK

U2 - 10.1080/13651500410000888

DO - 10.1080/13651500410000888

M3 - Article

VL - 8

SP - 169

EP - 171

JO - International Journal of Psychiatry in Clinical Practice

JF - International Journal of Psychiatry in Clinical Practice

SN - 1365-1501

IS - 3

ER -