A study to evaluate the use of extended release divalproex

Michael M. Stone, Robert M Hirschfeld

Research output: Contribution to journalReview articlepeer-review


BACKGROUND: Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS: The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS: Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS: This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.

Original languageEnglish (US)
Pages (from-to)169-171
Number of pages3
JournalInternational Journal of Psychiatry in Clinical Practice
Issue number3
StatePublished - Sep 2004
Externally publishedYes


  • Bipolar
  • Divalproex
  • Outpatient
  • Schizoaffective

ASJC Scopus subject areas

  • Psychiatry and Mental health


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