A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin

Hee Young Kim; Jigong Wang; Kyungsoon Chung; Jin Mo Chung

doi:10.1016/j.neulet.2008.06.074

A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin

Hee Young Kim, Jigong Wang, Kyungsoon Chung, Jin Mo Chung

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.

Original language	English (US)
Pages (from-to)	161-164
Number of pages	4
Journal	Neuroscience Letters
Volume	442
Issue number	2
DOIs	https://doi.org/10.1016/j.neulet.2008.06.074
State	Published - Sep 12 2008
Externally published	Yes

Keywords

Animal model
Lateral ankle ligament injury
Pain
Weight bearing

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2008.06.074

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title = "A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin",

abstract = "Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.",

keywords = "Animal model, Lateral ankle ligament injury, Pain, Weight bearing",

author = "Kim, {Hee Young} and Jigong Wang and Kyungsoon Chung and Chung, {Jin Mo}",

note = "Funding Information: This work was supported by an NIH/NCCAM grant R01 AT001474 and NIH/NINDS grants R01 NS 031680 and P01 NS 011255. We thank Ms. Denise Broker for her valuable assistance in editing the manuscript.",

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doi = "10.1016/j.neulet.2008.06.074",

language = "English (US)",

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AU - Kim, Hee Young

AU - Wang, Jigong

AU - Chung, Kyungsoon

AU - Chung, Jin Mo

N1 - Funding Information: This work was supported by an NIH/NCCAM grant R01 AT001474 and NIH/NINDS grants R01 NS 031680 and P01 NS 011255. We thank Ms. Denise Broker for her valuable assistance in editing the manuscript.

PY - 2008/9/12

Y1 - 2008/9/12

N2 - Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.

AB - Ankle sprain is a frequent injury in humans that results in pain, swelling and difficulty in walking on the affected side. Currently a suitable animal model resembling human ankle sprain is lacking. Here, we describe an animal ankle sprain model induced by ankle ligament injury (ALI) in rats. Cutting combinations of the lateral ankle ligament complex produced pain, edema and difficulty of weight bearing, thereby mimicking severe (grade III) ankle sprain in humans. Analgesic compounds, morphine and indomethacin, significantly reversed the reduced weight bearing, thus indicating that reduction of weight bearing is partially due to pain. The ALI model is a new ankle sprain model that may be useful for the study of ankle sprain pain mechanisms and treatments, as well as for the screening of new analgesic drugs.

KW - Animal model

KW - Lateral ankle ligament injury

KW - Pain

KW - Weight bearing

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A surgical ankle sprain pain model in the rat: Effects of morphine and indomethacin

Abstract

Keywords

ASJC Scopus subject areas

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