A surgical treatment for vitiligo

Autologous cultured-epithelial grafts

R. T. Plott, M. M. Brysk, R. C. Newton, Sharon Raimer, S. Rajaraman

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Medical treatment of vitiligo has been disappointing; therefore surgical treatments using autologous grafts have been tried. We investigated a new technique in which normally pigmented epidermal cells from a vitiligo patient were cultured on a collagen-coated membrane in MCDB-153, a media that supports melanocytes and keratinocytes. The cell/collagen-coated membrane was used to cover a superficially dermabraded vitiliginous area. Clinical repigmentation, though incomplete, was evident in three of four patients in 4 weeks. Immunofluorescence and electron microscopy were performed on the grafted areas (involved and uninvolved controls). These studies demonstrate the reappearance of melanocytes and melanosomes within the grafted area. All three patients who were successfully repigmented retained their pigment at 1 year follow-up. Further investigation of this promising treatment for vitiligo is warranted.

Original languageEnglish (US)
Pages (from-to)1161-1166
Number of pages6
JournalJournal of Dermatologic Surgery and Oncology
Volume15
Issue number11
StatePublished - 1989

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Vitiligo
Melanocytes
Transplants
Collagen
Melanosomes
Membranes
Keratinocytes
Fluorescence Microscopy
Electron Microscopy
Therapeutics

ASJC Scopus subject areas

  • Dermatology
  • Oncology

Cite this

Plott, R. T., Brysk, M. M., Newton, R. C., Raimer, S., & Rajaraman, S. (1989). A surgical treatment for vitiligo: Autologous cultured-epithelial grafts. Journal of Dermatologic Surgery and Oncology, 15(11), 1161-1166.

A surgical treatment for vitiligo : Autologous cultured-epithelial grafts. / Plott, R. T.; Brysk, M. M.; Newton, R. C.; Raimer, Sharon; Rajaraman, S.

In: Journal of Dermatologic Surgery and Oncology, Vol. 15, No. 11, 1989, p. 1161-1166.

Research output: Contribution to journalArticle

Plott, RT, Brysk, MM, Newton, RC, Raimer, S & Rajaraman, S 1989, 'A surgical treatment for vitiligo: Autologous cultured-epithelial grafts', Journal of Dermatologic Surgery and Oncology, vol. 15, no. 11, pp. 1161-1166.
Plott RT, Brysk MM, Newton RC, Raimer S, Rajaraman S. A surgical treatment for vitiligo: Autologous cultured-epithelial grafts. Journal of Dermatologic Surgery and Oncology. 1989;15(11):1161-1166.
Plott, R. T. ; Brysk, M. M. ; Newton, R. C. ; Raimer, Sharon ; Rajaraman, S. / A surgical treatment for vitiligo : Autologous cultured-epithelial grafts. In: Journal of Dermatologic Surgery and Oncology. 1989 ; Vol. 15, No. 11. pp. 1161-1166.
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