A survey of hantavirus antibody in small-mammal populations in selected United States National Parks

James N. Mills, Jerry M. Johnson, Thomas G. Ksiazek, Barbara A. Ellis, Pierre E. Rollin, Terry L. Yates, Michael O. Mann, Mark R. Johnson, Mariel L. Campbell, Jennifer Miyashiro, Michael Patrick, Michael Zyzak, Dave Lavender, Mark G. Novak, Karina Schmidt, C. J. Peters, James E. Childs

Research output: Contribution to journalArticle

80 Scopus citations


Hantavirus activity in 39 National Parks in the eastern and central United States was surveyed by testing 1,815 small mammals of 38 species for antibody reactive to Sin Nombre virus. Antibody-positive rodents were found throughout the area sampled, and in most biotic communities. Antibody was detected in 7% of 647 deer mice (Peromyscus maniculatus), 2% of 590 white- footed mice (P. leucopus), 17% of 12 rice rats (Oryzomys palustris), 3% of 31 cotton rats (Sigmodon hispidus), and 33% of 18 western harvest mice (Reithrodontomys megalotis). Antibody was also found in three of six species of voles, and in one of 33 chipmunks (Tamias minimus). Prevalence among Peromyscus was highest in the northeast. Although few cases of hantavirus pulmonary syndrome have been identified from the eastern and central regions, widespread infection in reservoir populations indicates that potential exists for human infection throughout much of the United States.

Original languageEnglish (US)
Pages (from-to)525-532
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number4
StatePublished - May 5 1998


ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

Cite this

Mills, J. N., Johnson, J. M., Ksiazek, T. G., Ellis, B. A., Rollin, P. E., Yates, T. L., Mann, M. O., Johnson, M. R., Campbell, M. L., Miyashiro, J., Patrick, M., Zyzak, M., Lavender, D., Novak, M. G., Schmidt, K., Peters, C. J., & Childs, J. E. (1998). A survey of hantavirus antibody in small-mammal populations in selected United States National Parks. American Journal of Tropical Medicine and Hygiene, 58(4), 525-532.