A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential

Zhiqiang Yu, Jie Li, Jinhang Zhu, Min Zhu, Feifei Jiang, Jin Zhang, Zhongwen Li, Mingkui Zhong, Justin Boy Kaye, Juan Du, Bing Shen

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Synthetic ion channels represent a new approach to mimicking natural ion channels and developing therapeutic drugs to restore ion channel dysfunction. The large superfamily of transient receptor potential (TRP) channels involved in numerous biological processes is an important and potent therapeutic target for various human diseases. In the present study, a synthetic peptide whose sequence is from the fourth transmembrane segment of TRPV4 is found that is capable of self-assembling into potassium (K+)-like ion channels designated as TRP-PK1 in the membranes of liposomes and live cells. TRP-PK1 effectively mediates K+ flow across the cell membrane to regulate the membrane potential. TRP-PK1 is also able to relax agonist-induced vessel contraction and regulate the resting blood pressure by hyperpolarizing the vascular smooth muscle cell membrane potential. TRP-PK1 represents a novel lead compound for mimicking K+ channels and treating hypertension, heart rate disorder and other K+ channel dysfunction-induced diseases. The present study also sheds new light onto the mimic ion channel function and the significant utilization of natural biological sources. This journal is

Original languageEnglish (US)
Pages (from-to)3809-3818
Number of pages10
JournalJournal of Materials Chemistry B
Volume2
Issue number24
DOIs
StatePublished - Jun 28 2014
Externally publishedYes

Fingerprint

Potassium Channels
Cell membranes
Ion Channels
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Potassium
Muscle
Cell Membrane
Ions
Lead compounds
Transient Receptor Potential Channels
Membranes
Biological Phenomena
Liposomes
Blood pressure
Peptides
Heart Rate
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomedical Engineering
  • Medicine(all)
  • Materials Science(all)

Cite this

A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential. / Yu, Zhiqiang; Li, Jie; Zhu, Jinhang; Zhu, Min; Jiang, Feifei; Zhang, Jin; Li, Zhongwen; Zhong, Mingkui; Kaye, Justin Boy; Du, Juan; Shen, Bing.

In: Journal of Materials Chemistry B, Vol. 2, No. 24, 28.06.2014, p. 3809-3818.

Research output: Contribution to journalArticle

Yu, Zhiqiang ; Li, Jie ; Zhu, Jinhang ; Zhu, Min ; Jiang, Feifei ; Zhang, Jin ; Li, Zhongwen ; Zhong, Mingkui ; Kaye, Justin Boy ; Du, Juan ; Shen, Bing. / A synthetic transmembrane segment derived from TRPV4 channel self-assembles into potassium-like channels to regulate vascular smooth muscle cell membrane potential. In: Journal of Materials Chemistry B. 2014 ; Vol. 2, No. 24. pp. 3809-3818.
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