A t(12;17) in an extraorbital giant cell angiofibroma

You Wen Qian, Rajit Malliah, Huey Jen Lee, Kasturi Das, Neena Mirani, Meera Hameed

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume165
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Qian, Y. W., Malliah, R., Lee, H. J., Das, K., Mirani, N., & Hameed, M. (2006). A t(12;17) in an extraorbital giant cell angiofibroma. Cancer Genetics and Cytogenetics, 165(2), 157-160. https://doi.org/10.1016/j.cancergencyto.2005.08.023