A t(12;17) in an extraorbital giant cell angiofibroma

You-Wen Qian, Rajit Malliah, Huey Jen Lee, Kasturi Das, Neena Mirani, Meera Hameed

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume165
Issue number2
DOIs
StatePublished - Mar 2006
Externally publishedYes

Fingerprint

Angiofibroma
Giant Cells
Chromosome Aberrations
Solitary Fibrous Tumors
Dermatofibrosarcoma
Karyotype
Microscopy
Chromosomes
Light

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A t(12;17) in an extraorbital giant cell angiofibroma. / Qian, You-Wen; Malliah, Rajit; Lee, Huey Jen; Das, Kasturi; Mirani, Neena; Hameed, Meera.

In: Cancer Genetics and Cytogenetics, Vol. 165, No. 2, 03.2006, p. 157-160.

Research output: Contribution to journalArticle

Qian, You-Wen ; Malliah, Rajit ; Lee, Huey Jen ; Das, Kasturi ; Mirani, Neena ; Hameed, Meera. / A t(12;17) in an extraorbital giant cell angiofibroma. In: Cancer Genetics and Cytogenetics. 2006 ; Vol. 165, No. 2. pp. 157-160.
@article{e513a301b1d840e7aa0e7763003f2c34,
title = "A t(12;17) in an extraorbital giant cell angiofibroma",
abstract = "We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.",
author = "You-Wen Qian and Rajit Malliah and Lee, {Huey Jen} and Kasturi Das and Neena Mirani and Meera Hameed",
year = "2006",
month = "3",
doi = "10.1016/j.cancergencyto.2005.08.023",
language = "English (US)",
volume = "165",
pages = "157--160",
journal = "Cancer Genetics and Cytogenetics",
issn = "0165-4608",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - A t(12;17) in an extraorbital giant cell angiofibroma

AU - Qian, You-Wen

AU - Malliah, Rajit

AU - Lee, Huey Jen

AU - Das, Kasturi

AU - Mirani, Neena

AU - Hameed, Meera

PY - 2006/3

Y1 - 2006/3

N2 - We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.

AB - We report a case of a 43-year-old male who presented with a large soft-tissue neck mass 7 years ago. A diagnosis of giant cell angiofibroma (GCA) was made on the basis of light microscopy and immunohistochemical studies. Chromosome analysis showed a male karyotype with t(12;17)(q15;q23),del(18)(q21) in all 20 cells analyzed. This cytogenetic abnormality in GCA is different from the t(17;22)(q22;q13) found in related lesions, such as giant cell fibroblastoma and solitary fibrous tumor, none of which has a specific chromosomal abnormality. Our case is the second case of GCA with chromosomal aberrations. To the best of our knowledge, this is the first case of GCA with t(12;17) occurring as an extra-orbital mass.

UR - http://www.scopus.com/inward/record.url?scp=33644777615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644777615&partnerID=8YFLogxK

U2 - 10.1016/j.cancergencyto.2005.08.023

DO - 10.1016/j.cancergencyto.2005.08.023

M3 - Article

VL - 165

SP - 157

EP - 160

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

SN - 0165-4608

IS - 2

ER -