A t(1;9)(q10;q10) translocation with additional 6q23 and 9q22 rearrangements in a case of chondromyxoid fibroma

Tahereh Dadfarnia, Gopalrao V N Velagaleti, Kelly Carmichael, Eduardo Eyzaguirre, Mahmoud A. Eltorky, Suimin Qiu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Chondromyxoid fibroma (CMF) is a rare cartilaginous tumor of bone. It typically presents in the long tubular bones and to a lesser extent in the small bones of the hands and feet of young adults. To date, several cytogenetic abnormalities have been described in association with CMF. We studied a phalangeal CMF from a 13-year-old female by cytogenetic methods. We found a novel unbalanced translocation between the long arms of chromosomes 1 and 9, resulting in loss of 1p. In addition, rearrangements involving the 6q23 and 9q22 regions were also observed. To our knowledge, this is the first report in the literature describing this novel chromosomal translocation in CMF.

Original languageEnglish (US)
Pages (from-to)666-670
Number of pages5
JournalCancer genetics
Volume204
Issue number12
DOIs
StatePublished - Dec 2011

Fingerprint

Fibroma
Foot Bones
Hand Bones
Bone and Bones
Chromosomes, Human, Pair 9
Genetic Translocation
Chromosomes, Human, Pair 1
Cytogenetics
Chromosome Aberrations
Young Adult
Neoplasms

Keywords

  • Chondromyxoid fibroma
  • Cytogenetics
  • T(1;9) translocation

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A t(1;9)(q10;q10) translocation with additional 6q23 and 9q22 rearrangements in a case of chondromyxoid fibroma. / Dadfarnia, Tahereh; Velagaleti, Gopalrao V N; Carmichael, Kelly; Eyzaguirre, Eduardo; Eltorky, Mahmoud A.; Qiu, Suimin.

In: Cancer genetics, Vol. 204, No. 12, 12.2011, p. 666-670.

Research output: Contribution to journalArticle

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AU - Eltorky, Mahmoud A.

AU - Qiu, Suimin

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