A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection

Panpan Yi, Yuejin Liang, Denley Ming Kee Yuan, Zuliang Jie, Zakari Kwota, Yan Chen, Yingzi Cong, Xuegong Fan, Jiaren Sun

Research output: Contribution to journalArticle

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Abstract

Interleukin-22 (IL-22) plays an important role in host immunity and tissue homeostasis in infectious and inflammatory diseases. However, the function and regulation of IL-22 in viral infection remain largely unknown. Here, we report that viral infection triggered early IL-22 production from the liver and lymphoid organs. γδ T cells are the main immune cells to produce IL-22 in the liver, a process mediated by the IL-23/phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway. In the presence of IL-23, IL-22 production is independent of aryl hydrocarbon receptor (AhR) signaling. In acute and persistent viral infections, IL-22 deficiency resulted in thymic and splenic hypertrophy, while excessive IL-22 induced atrophy in these lymphoid organs. Moreover, IL-22 deficiency enhanced T cell responses to promote viral clearance, but increased IL-22 in vivo decreased T cell numbers and functions in the liver and lymphoid tissues. Together, our findings reveal a significant effect of the IL-23/PI3K/mTORC1 axis on regulating IL-22 production and also identify a novel role of IL-22 in controlling antiviral T cell responses in the non-lymphoid and lymphoid organs during acute and persistent viral infections.

Original languageEnglish (US)
Article number3857
JournalScientific Reports
Volume7
Issue number1
DOIs
StatePublished - Dec 1 2017

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Virus Diseases
Homeostasis
Interleukin-23
T-Lymphocytes
1-Phosphatidylinositol 4-Kinase
Liver
interleukin-22
Aryl Hydrocarbon Receptors
Lymphoid Tissue
Hypertrophy
Atrophy
Antiviral Agents
Communicable Diseases
Immunity
Cell Count

ASJC Scopus subject areas

  • General

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A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. / Yi, Panpan; Liang, Yuejin; Yuan, Denley Ming Kee; Jie, Zuliang; Kwota, Zakari; Chen, Yan; Cong, Yingzi; Fan, Xuegong; Sun, Jiaren.

In: Scientific Reports, Vol. 7, No. 1, 3857, 01.12.2017.

Research output: Contribution to journalArticle

Yi, Panpan ; Liang, Yuejin ; Yuan, Denley Ming Kee ; Jie, Zuliang ; Kwota, Zakari ; Chen, Yan ; Cong, Yingzi ; Fan, Xuegong ; Sun, Jiaren. / A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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