A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator

Csaba Szabo

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    The history of H2S - as an environmental toxin - dates back to 1700, to the observations of the Italian physician Bernardino Ramazzini, whose book "De Morbis Artificum Diatriba" described the painful eye irritation and inflammation of "sewer gas" in sewer workers. The gas has subsequently been identified as hydrogen sulfide (H2S), and opened three centuries of research into the biological roles of H2S. The current article highlights the key discoveries in the field of H2S research, including (a) the toxicological studies, which characterized H2S as an environmental toxin, and identified some of its modes of action, including the inhibition of mitochondrial respiration; (b) work in the field of bacteriology, which, starting in the early 1900s, identified H2S as a bacterial product - with subsequently defined roles in the regulation of periodontal disease (oral bacterial flora), intestinal epithelial cell function (enteral bacterial flora) as well as in the regulation of bacterial resistance to antibiotics; and (c), work in diverse fields of mammalian biology, which, starting in the 1940s, identified H2S as an endogenous mammalian enzymatic product, the functions of which - among others, in the cardiovascular and nervous system - have become subjects of intensive investigation for the last decade. The current review not only enumerates the key discoveries related to H2S made over the last three centuries, but also compiles the most frequently cited papers in the field which have been published over the last decade and highlights some of the current 'hot topics' in the field of H2S biology.

    Original languageEnglish (US)
    JournalBiochemical Pharmacology
    DOIs
    StateAccepted/In press - 2017

    Fingerprint

    Biological Toxins
    Hydrogen Sulfide
    Sewers
    Bacteriology
    Gases
    Bacterial Drug Resistance
    Cardiovascular system
    Neurology
    Periodontal Diseases
    Cardiovascular System
    Research
    Toxicology
    Nervous System
    Small Intestine
    Respiration
    History
    Epithelial Cells
    Anti-Bacterial Agents
    Inflammation
    Physicians

    Keywords

    • 3-Mercaptopyruvate sulfurtransferase
    • Cystathionine gamma lyase
    • Cystathionine-β-synthase
    • Gasotransmitters
    • Nitric oxide

    ASJC Scopus subject areas

    • Biochemistry
    • Pharmacology

    Cite this

    A timeline of hydrogen sulfide (H2S) research : From environmental toxin to biological mediator. / Szabo, Csaba.

    In: Biochemical Pharmacology, 2017.

    Research output: Contribution to journalArticle

    @article{f1cb8c3106da41a8a67e33575cad8a09,
    title = "A timeline of hydrogen sulfide (H2S) research: From environmental toxin to biological mediator",
    abstract = "The history of H2S - as an environmental toxin - dates back to 1700, to the observations of the Italian physician Bernardino Ramazzini, whose book {"}De Morbis Artificum Diatriba{"} described the painful eye irritation and inflammation of {"}sewer gas{"} in sewer workers. The gas has subsequently been identified as hydrogen sulfide (H2S), and opened three centuries of research into the biological roles of H2S. The current article highlights the key discoveries in the field of H2S research, including (a) the toxicological studies, which characterized H2S as an environmental toxin, and identified some of its modes of action, including the inhibition of mitochondrial respiration; (b) work in the field of bacteriology, which, starting in the early 1900s, identified H2S as a bacterial product - with subsequently defined roles in the regulation of periodontal disease (oral bacterial flora), intestinal epithelial cell function (enteral bacterial flora) as well as in the regulation of bacterial resistance to antibiotics; and (c), work in diverse fields of mammalian biology, which, starting in the 1940s, identified H2S as an endogenous mammalian enzymatic product, the functions of which - among others, in the cardiovascular and nervous system - have become subjects of intensive investigation for the last decade. The current review not only enumerates the key discoveries related to H2S made over the last three centuries, but also compiles the most frequently cited papers in the field which have been published over the last decade and highlights some of the current 'hot topics' in the field of H2S biology.",
    keywords = "3-Mercaptopyruvate sulfurtransferase, Cystathionine gamma lyase, Cystathionine-β-synthase, Gasotransmitters, Nitric oxide",
    author = "Csaba Szabo",
    year = "2017",
    doi = "10.1016/j.bcp.2017.09.010",
    language = "English (US)",
    journal = "Biochemical Pharmacology",
    issn = "0006-2952",
    publisher = "Elsevier Inc.",

    }

    TY - JOUR

    T1 - A timeline of hydrogen sulfide (H2S) research

    T2 - From environmental toxin to biological mediator

    AU - Szabo, Csaba

    PY - 2017

    Y1 - 2017

    N2 - The history of H2S - as an environmental toxin - dates back to 1700, to the observations of the Italian physician Bernardino Ramazzini, whose book "De Morbis Artificum Diatriba" described the painful eye irritation and inflammation of "sewer gas" in sewer workers. The gas has subsequently been identified as hydrogen sulfide (H2S), and opened three centuries of research into the biological roles of H2S. The current article highlights the key discoveries in the field of H2S research, including (a) the toxicological studies, which characterized H2S as an environmental toxin, and identified some of its modes of action, including the inhibition of mitochondrial respiration; (b) work in the field of bacteriology, which, starting in the early 1900s, identified H2S as a bacterial product - with subsequently defined roles in the regulation of periodontal disease (oral bacterial flora), intestinal epithelial cell function (enteral bacterial flora) as well as in the regulation of bacterial resistance to antibiotics; and (c), work in diverse fields of mammalian biology, which, starting in the 1940s, identified H2S as an endogenous mammalian enzymatic product, the functions of which - among others, in the cardiovascular and nervous system - have become subjects of intensive investigation for the last decade. The current review not only enumerates the key discoveries related to H2S made over the last three centuries, but also compiles the most frequently cited papers in the field which have been published over the last decade and highlights some of the current 'hot topics' in the field of H2S biology.

    AB - The history of H2S - as an environmental toxin - dates back to 1700, to the observations of the Italian physician Bernardino Ramazzini, whose book "De Morbis Artificum Diatriba" described the painful eye irritation and inflammation of "sewer gas" in sewer workers. The gas has subsequently been identified as hydrogen sulfide (H2S), and opened three centuries of research into the biological roles of H2S. The current article highlights the key discoveries in the field of H2S research, including (a) the toxicological studies, which characterized H2S as an environmental toxin, and identified some of its modes of action, including the inhibition of mitochondrial respiration; (b) work in the field of bacteriology, which, starting in the early 1900s, identified H2S as a bacterial product - with subsequently defined roles in the regulation of periodontal disease (oral bacterial flora), intestinal epithelial cell function (enteral bacterial flora) as well as in the regulation of bacterial resistance to antibiotics; and (c), work in diverse fields of mammalian biology, which, starting in the 1940s, identified H2S as an endogenous mammalian enzymatic product, the functions of which - among others, in the cardiovascular and nervous system - have become subjects of intensive investigation for the last decade. The current review not only enumerates the key discoveries related to H2S made over the last three centuries, but also compiles the most frequently cited papers in the field which have been published over the last decade and highlights some of the current 'hot topics' in the field of H2S biology.

    KW - 3-Mercaptopyruvate sulfurtransferase

    KW - Cystathionine gamma lyase

    KW - Cystathionine-β-synthase

    KW - Gasotransmitters

    KW - Nitric oxide

    UR - http://www.scopus.com/inward/record.url?scp=85030550661&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=85030550661&partnerID=8YFLogxK

    U2 - 10.1016/j.bcp.2017.09.010

    DO - 10.1016/j.bcp.2017.09.010

    M3 - Article

    C2 - 28947277

    AN - SCOPUS:85030550661

    JO - Biochemical Pharmacology

    JF - Biochemical Pharmacology

    SN - 0006-2952

    ER -