A to Z: Vitamin A and zinc, the miracle duo

Edgar L. Molina, Janak Patel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Dietary micronutrients such as vitamins and trace minerals are known modulators of host immune responses against common pathogens. In this respect, vitamin A and zinc have recently received increased attention. Several in vivo and in vitro studies suggest that vitamin A may be a critical player in the mucosal immune responses in the respiratory and gastrointestinal tracts, particularly in undernourished children. The effect may be mediated primarily by stabilization of the membrane of mucosal epithelial cells, as well as enhanced leukocyte functions. The beneficial effect of vitamin A therapy in reducing measles-associated morbidity and mortality suggests its crucial role in defenses against viral pathogens. Zinc is also known affect leukocyte functions such as phagocytosis and T-lymphocyte-mediated immune responses. However, unlike vitamin A, zinc has been investigated primarily for its effects on bacterial infections. Dietary supplementation or therapeutic treatment with vitamin A and zinc may be a cheap yet effective means of preventing or treating infections in highly susceptible populations. Additional studies, however, are required to better define the types of pathogens and the specific human populations that may benefit from such therapy.

Original languageEnglish (US)
Pages (from-to)427-431
Number of pages5
JournalThe Indian Journal of Pediatrics
Volume63
Issue number4
DOIs
StatePublished - Jul 1996
Externally publishedYes

Fingerprint

Vitamin A
Zinc
Leukocytes
Mucosal Immunity
Micronutrients
Measles
Trace Elements
Therapeutics
Dietary Supplements
Phagocytosis
Bacterial Infections
Vitamins
Respiratory System
Population
Gastrointestinal Tract
Epithelial Cells
Morbidity
T-Lymphocytes
Membranes
Mortality

Keywords

  • Immunity
  • Nutrition
  • Vitamin A
  • Zinc

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A to Z : Vitamin A and zinc, the miracle duo. / Molina, Edgar L.; Patel, Janak.

In: The Indian Journal of Pediatrics, Vol. 63, No. 4, 07.1996, p. 427-431.

Research output: Contribution to journalArticle

Molina, Edgar L. ; Patel, Janak. / A to Z : Vitamin A and zinc, the miracle duo. In: The Indian Journal of Pediatrics. 1996 ; Vol. 63, No. 4. pp. 427-431.
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