A transferrin variant in a kindred with cystic fibrosis

Barbara H. Bowman, Don R. Barnett, Dorian Coppenhaver

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

An electrophoretically fast transferrin (Tf) variant, TfB, was found in a cystic fibrosis homozygote. Since neither cystic fibrosis nor the transferrin structural gene has been mapped on human chromosomes, a study was made of this kindred. Genetic markers including ABO, MN, Rh, Fy blood groups and Tf, group-specific component, and haptoglobin serum protein polymorphisms were determined in available members of the kindred. The genes for cystic fibrosis and Tf appear to segregate independently in the kindred, although crossing-over between linked genes in the homozygous cystic fibrosis brother of the propositus could account for the genotypes observed.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalHuman Heredity
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1981

Keywords

  • ABO
  • Gc
  • MN
  • Rh
  • Transferrin Cystic fibrosis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'A transferrin variant in a kindred with cystic fibrosis'. Together they form a unique fingerprint.

  • Cite this

    Bowman, B. H., Barnett, D. R., & Coppenhaver, D. (1981). A transferrin variant in a kindred with cystic fibrosis. Human Heredity, 31(4), 248-251. https://doi.org/10.1159/000153217