A transferrin variant in a kindred with cystic fibrosis

B. H. Bowman, D. R. Barnett, D. Coppenhaver

Research output: Contribution to journalArticle

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Abstract

An electrophoretically fast transferrin (Tf) variant, TfB, was found in a cystic fibrosis homozygote. Since neither cystic fibrosis nor the transferrin structural gene has been mapped on human chromosomes, a study was made of this kindred. Genetic markers including ABO, MN, Rh, Fy blood groups and Tf, group-specific component, and haptoglobin serum protein polymorphisms were determined in available members of the kindred. The genes for cystic fibrosis and Tf appear to segregate independently in the kindred, although crossing-over between linked genes in the homozygous cystic fibrosis brother of the propositus could account for the genotypes observed.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalHuman Heredity
Volume31
Issue number4
StatePublished - 1981

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Transferrin
Cystic Fibrosis
Genes
Haptoglobins
Homozygote
Human Chromosomes
Blood Group Antigens
Genetic Markers
Blood Proteins
Genotype

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Bowman, B. H., Barnett, D. R., & Coppenhaver, D. (1981). A transferrin variant in a kindred with cystic fibrosis. Human Heredity, 31(4), 248-251.

A transferrin variant in a kindred with cystic fibrosis. / Bowman, B. H.; Barnett, D. R.; Coppenhaver, D.

In: Human Heredity, Vol. 31, No. 4, 1981, p. 248-251.

Research output: Contribution to journalArticle

Bowman, BH, Barnett, DR & Coppenhaver, D 1981, 'A transferrin variant in a kindred with cystic fibrosis', Human Heredity, vol. 31, no. 4, pp. 248-251.
Bowman BH, Barnett DR, Coppenhaver D. A transferrin variant in a kindred with cystic fibrosis. Human Heredity. 1981;31(4):248-251.
Bowman, B. H. ; Barnett, D. R. ; Coppenhaver, D. / A transferrin variant in a kindred with cystic fibrosis. In: Human Heredity. 1981 ; Vol. 31, No. 4. pp. 248-251.
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