A tumor surveillance model: A non-coding RNA senses neoplastic cells and its protein partner signals cell death

Sung Ho Jeon, Betty H. Johnson, Yong Sun Lee

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

nc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide range of cancer cells, the nc886-PKR relationship suggests a tumor surveillance model. When neoplastic cells develop and nc886 decreases therein, PKR is released from nc886 and becomes the active phosphorylated form, which initiates an apoptotic cascade to eliminate those cells. The nc886-PKR pathway is distinct from conventional mechanisms, such as the immune surveillance hypothesis or intrinsic mechanisms that check/proofread the genomic integrity, and thus represents a novel example of tumor surveillance.

Original languageEnglish (US)
Pages (from-to)13134-13139
Number of pages6
JournalInternational journal of molecular sciences
Volume13
Issue number10
DOIs
StatePublished - Oct 2012

Keywords

  • Nc886
  • Non-coding rna
  • Pkr (protein kinase r)
  • Surveillance
  • Tumor

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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