A tumor surveillance model

A non-coding RNA senses neoplastic cells and its protein partner signals cell death

Sung Ho Jeon, Betty H. Johnson, Yong Sun Lee

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    nc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide range of cancer cells, the nc886-PKR relationship suggests a tumor surveillance model. When neoplastic cells develop and nc886 decreases therein, PKR is released from nc886 and becomes the active phosphorylated form, which initiates an apoptotic cascade to eliminate those cells. The nc886-PKR pathway is distinct from conventional mechanisms, such as the immune surveillance hypothesis or intrinsic mechanisms that check/proofread the genomic integrity, and thus represents a novel example of tumor surveillance.

    Original languageEnglish (US)
    Pages (from-to)13134-13139
    Number of pages6
    JournalInternational Journal of Molecular Sciences
    Volume13
    Issue number10
    DOIs
    StatePublished - 2012

    Fingerprint

    Untranslated RNA
    Cell death
    surveillance
    RNA
    death
    Protein Kinases
    Tumors
    Cell Death
    tumors
    proteins
    Proteins
    cells
    Neoplasms
    Repressor Proteins
    integrity
    cascades
    cancer
    Cells
    retarding

    Keywords

    • Nc886
    • Non-coding rna
    • Pkr (protein kinase r)
    • Surveillance
    • Tumor

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry
    • Organic Chemistry
    • Spectroscopy
    • Inorganic Chemistry
    • Catalysis
    • Molecular Biology
    • Computer Science Applications
    • Medicine(all)

    Cite this

    A tumor surveillance model : A non-coding RNA senses neoplastic cells and its protein partner signals cell death. / Jeon, Sung Ho; Johnson, Betty H.; Lee, Yong Sun.

    In: International Journal of Molecular Sciences, Vol. 13, No. 10, 2012, p. 13134-13139.

    Research output: Contribution to journalArticle

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