@article{1a8ad9b4fb5245be994b46fef9ab9180,
title = "A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates",
abstract = " Recent and ongoing outbreaks of Ebola virus disease (EVD) underscore the unpredictable nature of ebolavirus reemergence and the urgent need for antiviral treatments. Unfortunately, available experimental vaccines and immunotherapeutics are specific for a single member of the Ebolavirus genus, Ebola virus (EBOV), and ineffective against other ebolaviruses associated with EVD, including Sudan virus (SUDV) and Bundibugyo virus (BDBV). Here we show that MBP134 AF , a pan-ebolavirus therapeutic comprising two broadly neutralizing human antibodies (bNAbs), affords unprecedented effectiveness and potency as a therapeutic countermeasure to antigenically diverse ebolaviruses. MBP134 AF could fully protect ferrets against lethal EBOV, SUDV, and BDBV infection, and a single 25-mg/kg dose was sufficient to protect NHPs against all three viruses. The development of MBP134 AF provides a successful model for the rapid discovery and translational advancement of immunotherapeutics targeting emerging infectious diseases.",
keywords = "ADI-15878, ADI-23774, BDBV, Bundibugyo, EBOV, MBP134, SUDV, Sudan, ebolavirus, pan-ebolavirus",
author = "Bornholdt, {Zachary A.} and Herbert, {Andrew S.} and Mire, {Chad E.} and Shihua He and Cross, {Robert W.} and Wec, {Anna Z.} and Abelson, {Dafna M.} and Geisbert, {Joan B.} and James, {Rebekah M.} and Rahim, {Md Niaz} and Wenjun Zhu and Viktoriya Borisevich and Logan Banadyga and Gunn, {Bronwyn M.} and Agans, {Krystle N.} and Wirchnianski, {Ariel S.} and Eileen Goodwin and Kevin Tierney and Shestowsky, {William S.} and Ognian Bohorov and Natasha Bohorova and Jesus Velasco and Eric Ailor and Do Kim and Pauly, {Michael H.} and Whaley, {Kevin J.} and Galit Alter and Walker, {Laura M.} and Kartik Chandran and Larry Zeitlin and Xiangguo Qiu and Geisbert, {Thomas W.} and Dye, {John M.}",
note = "Funding Information: This project has been funded in part with federal funds from the Department of Defense under Contract No. HDTRA1-13-C-0018, the Department of Health and Human Services{\textquoteright} NIH (U19AI109711, U19AI109762, and AI132256), the Public Health Agency of Canada (PHAC), Office of the Assistant Secretary for Preparedness and Response, and Biomedical Advanced Research and Development Authority (BARDA), under Contract No. HHSO100201700023C. K.C. was additionally supported by an Irma T. Hirschl/Monique Weill-Caulier Research Award. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. Funding Information: This project has been funded in part with federal funds from the Department of Defense under Contract No. HDTRA1-13-C-0018, the Department of Health and Human Services{\textquoteright} NIH ( U19AI109711 , U19AI109762 , and AI132256 ), the Public Health Agency of Canada (PHAC), Office of the Assistant Secretary for Preparedness and Response , and Biomedical Advanced Research and Development Authority (BARDA), under Contract No. HHSO100201700023C. K.C. was additionally supported by an Irma T. Hirschl/Monique Weill-Caulier Research Award. Opinions, conclusions, interpretations, and recommendations are those of the authors and are not necessarily endorsed by the U.S. Army. The mention of trade names or commercial products does not constitute endorsement or recommendation for use by the Department of the Army or the Department of Defense. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "9",
doi = "10.1016/j.chom.2018.12.005",
language = "English (US)",
volume = "25",
pages = "49--58.e5",
journal = "Cell Host and Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "1",
}