A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

Joshua C. Chen, Peter Kan, Zhanghao Yu, Fatima Alrashdan, Roberto Garcia, Amanda Singer, C. S.Edwin Lai, Ben Avants, Scott Crosby, Zhongxi Li, Boshuo Wang, Michelle M. Felicella, Ariadna Robledo, Angel V. Peterchev, Stefan M. Goetz, Jeffrey D. Hartgerink, Sunil A. Sheth, Kaiyuan Yang, Jacob T. Robinson

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Implantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.

Original languageEnglish (US)
Pages (from-to)706-716
Number of pages11
JournalNature Biomedical Engineering
Volume6
Issue number6
DOIs
StatePublished - Jun 2022

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

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