A within-subject analysis of d-amphetamine exposure on delay discounting in rats

Jonathan M. Slezak, Christopher A. Krebs, Karen G. Anderson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Studies concerning the relation between stimulant drug exposure and subsequent delay discounting (impulsive choice) have resulted in mixed findings that could be related to the type of stimulant drug exposure or the use of between-subject comparisons. The purpose of the present study was to examine effects of prior d-amphetamine exposure on subsequent delay discounting using a within-subject assessment. Two groups of rats were trained under a discrete-trials choice procedure until delay discounting was stable. One group of rats then received repeated administration of 3.0 mg/kg d-amphetamine in their home cage for 14 consecutive days, while the other group received saline. After a three-week drug-free period, delay discounting was reassessed. No significant differences in area under the curve within (before or after drug exposure) or between (saline or d-amphetamine) groups were found. Thus, delay discounting was not systematically affected following termination of repeated 3.0 mg/kg d-amphetamine exposure in the present experimental arrangement. The current results, coupled with past research, indicate that there may be a distinction between cocaine exposure and d-amphetamine exposure on subsequent delay discounting; however, within-subject comparisons of cocaine exposure on delay discounting are warranted.

Original languageEnglish (US)
Pages (from-to)502-505
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume102
Issue number4
DOIs
StatePublished - Oct 2012
Externally publishedYes

Fingerprint

Dextroamphetamine
Rats
Cocaine
Pharmaceutical Preparations
Delay Discounting
Area Under Curve
Research

Keywords

  • D-amphetamine
  • Delay discounting
  • Impulsive choice
  • Rat
  • Repeated administration

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Toxicology
  • Behavioral Neuroscience
  • Biological Psychiatry

Cite this

A within-subject analysis of d-amphetamine exposure on delay discounting in rats. / Slezak, Jonathan M.; Krebs, Christopher A.; Anderson, Karen G.

In: Pharmacology Biochemistry and Behavior, Vol. 102, No. 4, 10.2012, p. 502-505.

Research output: Contribution to journalArticle

Slezak, Jonathan M. ; Krebs, Christopher A. ; Anderson, Karen G. / A within-subject analysis of d-amphetamine exposure on delay discounting in rats. In: Pharmacology Biochemistry and Behavior. 2012 ; Vol. 102, No. 4. pp. 502-505.
@article{bc4e6b173e6f4feb9a05a44b3ec0920c,
title = "A within-subject analysis of d-amphetamine exposure on delay discounting in rats",
abstract = "Studies concerning the relation between stimulant drug exposure and subsequent delay discounting (impulsive choice) have resulted in mixed findings that could be related to the type of stimulant drug exposure or the use of between-subject comparisons. The purpose of the present study was to examine effects of prior d-amphetamine exposure on subsequent delay discounting using a within-subject assessment. Two groups of rats were trained under a discrete-trials choice procedure until delay discounting was stable. One group of rats then received repeated administration of 3.0 mg/kg d-amphetamine in their home cage for 14 consecutive days, while the other group received saline. After a three-week drug-free period, delay discounting was reassessed. No significant differences in area under the curve within (before or after drug exposure) or between (saline or d-amphetamine) groups were found. Thus, delay discounting was not systematically affected following termination of repeated 3.0 mg/kg d-amphetamine exposure in the present experimental arrangement. The current results, coupled with past research, indicate that there may be a distinction between cocaine exposure and d-amphetamine exposure on subsequent delay discounting; however, within-subject comparisons of cocaine exposure on delay discounting are warranted.",
keywords = "D-amphetamine, Delay discounting, Impulsive choice, Rat, Repeated administration",
author = "Slezak, {Jonathan M.} and Krebs, {Christopher A.} and Anderson, {Karen G.}",
year = "2012",
month = "10",
doi = "10.1016/j.pbb.2012.06.019",
language = "English (US)",
volume = "102",
pages = "502--505",
journal = "Pharmacology Biochemistry and Behavior",
issn = "0091-3057",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - A within-subject analysis of d-amphetamine exposure on delay discounting in rats

AU - Slezak, Jonathan M.

AU - Krebs, Christopher A.

AU - Anderson, Karen G.

PY - 2012/10

Y1 - 2012/10

N2 - Studies concerning the relation between stimulant drug exposure and subsequent delay discounting (impulsive choice) have resulted in mixed findings that could be related to the type of stimulant drug exposure or the use of between-subject comparisons. The purpose of the present study was to examine effects of prior d-amphetamine exposure on subsequent delay discounting using a within-subject assessment. Two groups of rats were trained under a discrete-trials choice procedure until delay discounting was stable. One group of rats then received repeated administration of 3.0 mg/kg d-amphetamine in their home cage for 14 consecutive days, while the other group received saline. After a three-week drug-free period, delay discounting was reassessed. No significant differences in area under the curve within (before or after drug exposure) or between (saline or d-amphetamine) groups were found. Thus, delay discounting was not systematically affected following termination of repeated 3.0 mg/kg d-amphetamine exposure in the present experimental arrangement. The current results, coupled with past research, indicate that there may be a distinction between cocaine exposure and d-amphetamine exposure on subsequent delay discounting; however, within-subject comparisons of cocaine exposure on delay discounting are warranted.

AB - Studies concerning the relation between stimulant drug exposure and subsequent delay discounting (impulsive choice) have resulted in mixed findings that could be related to the type of stimulant drug exposure or the use of between-subject comparisons. The purpose of the present study was to examine effects of prior d-amphetamine exposure on subsequent delay discounting using a within-subject assessment. Two groups of rats were trained under a discrete-trials choice procedure until delay discounting was stable. One group of rats then received repeated administration of 3.0 mg/kg d-amphetamine in their home cage for 14 consecutive days, while the other group received saline. After a three-week drug-free period, delay discounting was reassessed. No significant differences in area under the curve within (before or after drug exposure) or between (saline or d-amphetamine) groups were found. Thus, delay discounting was not systematically affected following termination of repeated 3.0 mg/kg d-amphetamine exposure in the present experimental arrangement. The current results, coupled with past research, indicate that there may be a distinction between cocaine exposure and d-amphetamine exposure on subsequent delay discounting; however, within-subject comparisons of cocaine exposure on delay discounting are warranted.

KW - D-amphetamine

KW - Delay discounting

KW - Impulsive choice

KW - Rat

KW - Repeated administration

UR - http://www.scopus.com/inward/record.url?scp=84864151322&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864151322&partnerID=8YFLogxK

U2 - 10.1016/j.pbb.2012.06.019

DO - 10.1016/j.pbb.2012.06.019

M3 - Article

C2 - 22750554

AN - SCOPUS:84864151322

VL - 102

SP - 502

EP - 505

JO - Pharmacology Biochemistry and Behavior

JF - Pharmacology Biochemistry and Behavior

SN - 0091-3057

IS - 4

ER -