Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours

F. Suzuki, R. R. Brutkiewicz, R. B. Pollard

Research output: Contribution to journalArticle

Abstract

Sera from C57B1/6 mice treated orally with Ge-132 exhibited antitumour activity against Ehrlich (allogeneic) and RL♂1 (syngeneic) ascites tumours in BALB/c mice. Sera obtained from mice 24 h after Ge-132 administration displayed the greatest antitumour effect and this was dose dependent. Sera prepared from mice 12, 36, or 48 h after Ge-132 treatment had no protective effect. Circulating interferon (IFN) was induced at 24 h after administration of Ge-132 but was not detected in the sera at 12, 36, or 48 h after administration. The antiviral activity of sera from Ge-132 treated mice was inactivated by treatments with trypsin, low pH, and anti-IFNγ antiserum. The inactivated preparations of serum IFN induced by Ge-132 did not exhibit antitumour activity when administered to tumour-bearing mice. These results suggest that antitumour activity in the sera of Ge-132-treated mice may be expressed through activities of Ge-132-induced lymphokine(s), such as IFNγ.

Original languageEnglish (US)
Pages (from-to)757-763
Number of pages7
JournalBritish Journal of Cancer
Volume52
Issue number5
StatePublished - 1985
Externally publishedYes

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Germanium
Ascites
Serum
Interferons
Neoplasms
proxigermanium
Lymphokines
Trypsin
Antiviral Agents
Immune Sera

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ability of sera from mice treated with Ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours. / Suzuki, F.; Brutkiewicz, R. R.; Pollard, R. B.

In: British Journal of Cancer, Vol. 52, No. 5, 1985, p. 757-763.

Research output: Contribution to journalArticle

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