Ability of sera from mice treated with ge-132, an organic germanium compound, to inhibit experimental murine ascites tumours

Fujio Suzuki, R. R. Brutkiewicz, R. B. Pollard

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36 Scopus citations

Abstract

Sera from C57B1/6 mice treated orally with Ge-132 exhibited antitumour activity against Ehrlich (allogeneic) and RL♂I (syngeneic) ascites tumours in BALB/c mice. Sera obtained from mice 24 h after Ge-132 administration displayed the greatest antitumour effect and this was dose dependent. Sera prepared from mice 12, 36, or 48h after Ge-132 treatment had no protective effect. Circulating interferon (IFN) was induced at 24 h after administration of Ge-132 but was not detected in the sera at 12, 36, or 48 h after administration. The antiviral activity of sera from Ge-132-treated mice was inactivated by treatments with trypsin, low pH, and anti-IFNγ antiserum. The inactivated preparations of serum IFN induced by Ge-132 did not exhibit antitumour activity when administered to tumour-bearing mice. These results suggest that antitumour activity in the sera of Ge-132-treated mice may be expressed through activities of Ge-132-induced lymphokine(s), such as IFNγ.

Original languageEnglish (US)
Pages (from-to)747-755
Number of pages9
JournalBritish Journal of Cancer
Volume52
Issue number5
DOIs
StatePublished - 1985

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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