Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM

Nicola Abate; Gloria Lena Vega; Abhimanyu Garg; Scott M. Grundy

doi:10.1016/0021-9150(95)05597-P

Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM

Nicola Abate, Gloria Lena Vega, Abhimanyu Garg, Scott M. Grundy

Internal Medicine

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31 Scopus citations

Abstract

This study was carried out to identify and define lipoprotein abnormalities in patients with noninsulin-dependent diabetes mellitus (NIDDM) who do not have clinical elevations of cholesterol or triglycerides. Thirty-four male patients with mild NIDDM and normolipidemia (plasma cholesterol ≤ 240 mg/dl and triglycerides ≤ 250 mg/dl) were compared with 35 healthy male normolipidemic subjects. The two groups had similar age and body mass index. Measurements in the two groups included concentrations and chemical composition of lipoproteins and sizing of low-density lipoprotein (LDL) particles. The patients with NIDDM, compared to control subjects, had two distinct lipoprotein abnormalities: first, a significantly reduced level of high-density lipoprotein (HDL) cholesterol (mean ± S.D., 35 ± 8 mg/dl vs. 41 ± 10 mg/dl, respectively; P = 0.006); and second, a high cholesterol-to-apolipoprotein (apo) B ratio both in very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) fraction (mean ± S.D.; 3.2 ± 0.8 vs. 2.8 ± 0.9, respectively; P = 0.02) and in LDL fraction (mean ± S.D.; 1.61 ± 0.11 vs. 1.52 ± 0.13, respectively; P = 0.003). Increased cholesterol content in LDL was mainly due to free cholesterol. No differences were detected between the two groups in the frequency of LDL pattern A (major LDL peak > 255 Å) and pattern B (major LDL peak ≤ 255 Å). However, a higher frequency of LDL pattern B was found in NIDDM patients with low plasma total triglycerides concentrations (< 150 mg/dl) compared to the control subjects (45% vs. 7%, P = 0.02). Thus in normolipidemic patients with mild NIDDM, the major lipoprotein abnormalities were a low level of HDL cholesterol and compositional changes in LDL and VLDL + IDL fractions. Compositional abnormalities included enrichment of apo B-containing lipoproteins with cholesterol. These lipoprotein abnormalities could have atherogenic potential in patients with mild NIDDM and normolipidemia.

Original language	English (US)
Pages (from-to)	111-122
Number of pages	12
Journal	Atherosclerosis
Volume	118
Issue number	1
DOIs	https://doi.org/10.1016/0021-9150(95)05597-P
State	Published - Nov 1995

Keywords

Atherosclerosis
LDL pattern
Lipoproteins
NIDDM
Normolipidemia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/0021-9150(95)05597-P

Cite this

@article{df3a1382a3cd4083b96af8435316851a,

title = "Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM",

abstract = "This study was carried out to identify and define lipoprotein abnormalities in patients with noninsulin-dependent diabetes mellitus (NIDDM) who do not have clinical elevations of cholesterol or triglycerides. Thirty-four male patients with mild NIDDM and normolipidemia (plasma cholesterol ≤ 240 mg/dl and triglycerides ≤ 250 mg/dl) were compared with 35 healthy male normolipidemic subjects. The two groups had similar age and body mass index. Measurements in the two groups included concentrations and chemical composition of lipoproteins and sizing of low-density lipoprotein (LDL) particles. The patients with NIDDM, compared to control subjects, had two distinct lipoprotein abnormalities: first, a significantly reduced level of high-density lipoprotein (HDL) cholesterol (mean ± S.D., 35 ± 8 mg/dl vs. 41 ± 10 mg/dl, respectively; P = 0.006); and second, a high cholesterol-to-apolipoprotein (apo) B ratio both in very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) fraction (mean ± S.D.; 3.2 ± 0.8 vs. 2.8 ± 0.9, respectively; P = 0.02) and in LDL fraction (mean ± S.D.; 1.61 ± 0.11 vs. 1.52 ± 0.13, respectively; P = 0.003). Increased cholesterol content in LDL was mainly due to free cholesterol. No differences were detected between the two groups in the frequency of LDL pattern A (major LDL peak > 255 {\AA}) and pattern B (major LDL peak ≤ 255 {\AA}). However, a higher frequency of LDL pattern B was found in NIDDM patients with low plasma total triglycerides concentrations (< 150 mg/dl) compared to the control subjects (45% vs. 7%, P = 0.02). Thus in normolipidemic patients with mild NIDDM, the major lipoprotein abnormalities were a low level of HDL cholesterol and compositional changes in LDL and VLDL + IDL fractions. Compositional abnormalities included enrichment of apo B-containing lipoproteins with cholesterol. These lipoprotein abnormalities could have atherogenic potential in patients with mild NIDDM and normolipidemia.",

keywords = "Atherosclerosis, LDL pattern, Lipoproteins, NIDDM, Normolipidemia",

author = "Nicola Abate and Vega, {Gloria Lena} and Abhimanyu Garg and Grundy, {Scott M.}",

note = "Funding Information: The authors wish to expressa ppreciationf or the excellentt echnicala ssistanceo f Kathy Schutt, Margaret Arnecke and Anh Nguyen. The assistance of Marjorie Whelan, clinical staffs of the Metabolic Ward of the Departmento f Veterans Affairs Medical Center,a nd of the General Clinical Research Center (GCRC) is gratefully acknowledged. Beverley Adams Huet, MS., biostatisticiano f the GCRC, assistedin the analysis of the data. This studyw as supportedb y the Departmento f Veterans Affairs, National Institutes of Health, grantsH L-29252a nd MOl-RR00633, The South-westernM edical Foundation and the Moss Heart Foundation, Dallas, TX. This study was also supported by an unrestricted nutrition award from the Bristol-Myers-SquibbF oundation Inc.",

year = "1995",

month = nov,

doi = "10.1016/0021-9150(95)05597-P",

language = "English (US)",

volume = "118",

pages = "111--122",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM

AU - Abate, Nicola

AU - Vega, Gloria Lena

AU - Garg, Abhimanyu

AU - Grundy, Scott M.

N1 - Funding Information: The authors wish to expressa ppreciationf or the excellentt echnicala ssistanceo f Kathy Schutt, Margaret Arnecke and Anh Nguyen. The assistance of Marjorie Whelan, clinical staffs of the Metabolic Ward of the Departmento f Veterans Affairs Medical Center,a nd of the General Clinical Research Center (GCRC) is gratefully acknowledged. Beverley Adams Huet, MS., biostatisticiano f the GCRC, assistedin the analysis of the data. This studyw as supportedb y the Departmento f Veterans Affairs, National Institutes of Health, grantsH L-29252a nd MOl-RR00633, The South-westernM edical Foundation and the Moss Heart Foundation, Dallas, TX. This study was also supported by an unrestricted nutrition award from the Bristol-Myers-SquibbF oundation Inc.

PY - 1995/11

Y1 - 1995/11

N2 - This study was carried out to identify and define lipoprotein abnormalities in patients with noninsulin-dependent diabetes mellitus (NIDDM) who do not have clinical elevations of cholesterol or triglycerides. Thirty-four male patients with mild NIDDM and normolipidemia (plasma cholesterol ≤ 240 mg/dl and triglycerides ≤ 250 mg/dl) were compared with 35 healthy male normolipidemic subjects. The two groups had similar age and body mass index. Measurements in the two groups included concentrations and chemical composition of lipoproteins and sizing of low-density lipoprotein (LDL) particles. The patients with NIDDM, compared to control subjects, had two distinct lipoprotein abnormalities: first, a significantly reduced level of high-density lipoprotein (HDL) cholesterol (mean ± S.D., 35 ± 8 mg/dl vs. 41 ± 10 mg/dl, respectively; P = 0.006); and second, a high cholesterol-to-apolipoprotein (apo) B ratio both in very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) fraction (mean ± S.D.; 3.2 ± 0.8 vs. 2.8 ± 0.9, respectively; P = 0.02) and in LDL fraction (mean ± S.D.; 1.61 ± 0.11 vs. 1.52 ± 0.13, respectively; P = 0.003). Increased cholesterol content in LDL was mainly due to free cholesterol. No differences were detected between the two groups in the frequency of LDL pattern A (major LDL peak > 255 Å) and pattern B (major LDL peak ≤ 255 Å). However, a higher frequency of LDL pattern B was found in NIDDM patients with low plasma total triglycerides concentrations (< 150 mg/dl) compared to the control subjects (45% vs. 7%, P = 0.02). Thus in normolipidemic patients with mild NIDDM, the major lipoprotein abnormalities were a low level of HDL cholesterol and compositional changes in LDL and VLDL + IDL fractions. Compositional abnormalities included enrichment of apo B-containing lipoproteins with cholesterol. These lipoprotein abnormalities could have atherogenic potential in patients with mild NIDDM and normolipidemia.

AB - This study was carried out to identify and define lipoprotein abnormalities in patients with noninsulin-dependent diabetes mellitus (NIDDM) who do not have clinical elevations of cholesterol or triglycerides. Thirty-four male patients with mild NIDDM and normolipidemia (plasma cholesterol ≤ 240 mg/dl and triglycerides ≤ 250 mg/dl) were compared with 35 healthy male normolipidemic subjects. The two groups had similar age and body mass index. Measurements in the two groups included concentrations and chemical composition of lipoproteins and sizing of low-density lipoprotein (LDL) particles. The patients with NIDDM, compared to control subjects, had two distinct lipoprotein abnormalities: first, a significantly reduced level of high-density lipoprotein (HDL) cholesterol (mean ± S.D., 35 ± 8 mg/dl vs. 41 ± 10 mg/dl, respectively; P = 0.006); and second, a high cholesterol-to-apolipoprotein (apo) B ratio both in very low density lipoprotein (VLDL) + intermediate density lipoprotein (IDL) fraction (mean ± S.D.; 3.2 ± 0.8 vs. 2.8 ± 0.9, respectively; P = 0.02) and in LDL fraction (mean ± S.D.; 1.61 ± 0.11 vs. 1.52 ± 0.13, respectively; P = 0.003). Increased cholesterol content in LDL was mainly due to free cholesterol. No differences were detected between the two groups in the frequency of LDL pattern A (major LDL peak > 255 Å) and pattern B (major LDL peak ≤ 255 Å). However, a higher frequency of LDL pattern B was found in NIDDM patients with low plasma total triglycerides concentrations (< 150 mg/dl) compared to the control subjects (45% vs. 7%, P = 0.02). Thus in normolipidemic patients with mild NIDDM, the major lipoprotein abnormalities were a low level of HDL cholesterol and compositional changes in LDL and VLDL + IDL fractions. Compositional abnormalities included enrichment of apo B-containing lipoproteins with cholesterol. These lipoprotein abnormalities could have atherogenic potential in patients with mild NIDDM and normolipidemia.

KW - Atherosclerosis

KW - LDL pattern

KW - Lipoproteins

KW - NIDDM

KW - Normolipidemia

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DO - 10.1016/0021-9150(95)05597-P

M3 - Article

C2 - 8579621

AN - SCOPUS:0028886350

SN - 0021-9150

VL - 118

SP - 111

EP - 122

JO - Atherosclerosis

JF - Atherosclerosis

IS - 1

ER -

Abnormal cholesterol distribution among lipoprotein fractions in normolipidemic patients with mild NIDDM

Abstract

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ASJC Scopus subject areas

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