Abnormal oxidative metabolism of estradiol in women with breast cancer

J. Schneider, D. Kinne, A. Fracchia, V. Pierce, Karl Anderson, H. L. Bradlow, J. Fishman

Research output: Contribution to journalArticle

220 Citations (Scopus)

Abstract

The three dominant oxidative biotransformations of estradiol were examined in 10 normal women and 33 females with breast cancer by using a recently devised radiometric method. Estradiol tracers, labeled with 3H specifically in the 17α, C-2, or 16α position, were used to measure both the rate and extent of 17β-ol oxidation (the initial metabolic step) and the subsequent 2- and 16α-oxidative reactions. The mean ± SEM values for the extent of estradiol metabolism at these three specific sites were 76.9 ± 5.3%, 31.1 ± 4.0%, and 9.3 ± 0.8%, respectively, in normal subjects. Corresponding data in patients with breast cancer - i.e., 73.0 ± 4.2%, 32.7 ± 2.7%, and 14.9 ± 1.5% - revealed a significantly greater extent of 16α-hydroxylation in the latter population. Because the 16α-hydroxylated compounds (including estriol) are themseleves potent estrogens, these changes may have important hyperestrogenic consequences that could have a bearing on the etiology of the disease.

Original languageEnglish (US)
Pages (from-to)3047-3051
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume79
Issue number9 I
DOIs
StatePublished - 1982
Externally publishedYes

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Estradiol
Breast Neoplasms
Estriol
Hydroxylation
Biotransformation
Estrogens
Population

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Abnormal oxidative metabolism of estradiol in women with breast cancer. / Schneider, J.; Kinne, D.; Fracchia, A.; Pierce, V.; Anderson, Karl; Bradlow, H. L.; Fishman, J.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, No. 9 I, 1982, p. 3047-3051.

Research output: Contribution to journalArticle

Schneider, J. ; Kinne, D. ; Fracchia, A. ; Pierce, V. ; Anderson, Karl ; Bradlow, H. L. ; Fishman, J. / Abnormal oxidative metabolism of estradiol in women with breast cancer. In: Proceedings of the National Academy of Sciences of the United States of America. 1982 ; Vol. 79, No. 9 I. pp. 3047-3051.
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