Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice

Hiroshi Gohma, Takashi Kuramoto, Reuben Matalon, Sankar Surendran, Stephen Tyring, Kazuhiro Kitada, Masashi Sasa, Tadao Serikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The Spontaneously Epileptic Rat (SER), a double-mutant for tremor and zitter mutations, shows spontaneous occurrences of absence-like and tonic seizures. Several lines of evidence suggest that the combined effect of Aspa and Atrn mutations is the most likely cause of the epileptic phenotype of the SER. To address this issue, we produced a new double-mutant mouse line carrying both homozygous Aspa-knockout and Atrnmg-3J mutant alleles. The Aspa/Atrn double-mutant mice exhibited absence-like and tonic seizures that were characterized by the appearance of 5-7 Hz spike-wave-like complexes and low voltage fast waves on EEGs. These results demonstrate directly that the simultaneous loss of the Aspa and Atrn gene functions causes epileptic seizures in the mouse and suggest that both Aspa and Atrn deficiencies might be responsible for epileptic seizures in the SER.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalExperimental Animals
Volume56
Issue number2
DOIs
StatePublished - Apr 26 2007

Fingerprint

Absence Epilepsy
seizures
Rats
Seizures
mutants
Epilepsy
mice
rats
Mutation
Tremor
Electroencephalography
mutation
Genes
Alleles
Phenotype
Electric potential
alleles
phenotype
aspartoacylase
genes

Keywords

  • Aspartoacylase
  • Attractin
  • Epilepsy

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Gohma, H., Kuramoto, T., Matalon, R., Surendran, S., Tyring, S., Kitada, K., ... Serikawa, T. (2007). Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice. Experimental Animals, 56(2), 161-165. https://doi.org/10.1538/expanim.56.161

Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice. / Gohma, Hiroshi; Kuramoto, Takashi; Matalon, Reuben; Surendran, Sankar; Tyring, Stephen; Kitada, Kazuhiro; Sasa, Masashi; Serikawa, Tadao.

In: Experimental Animals, Vol. 56, No. 2, 26.04.2007, p. 161-165.

Research output: Contribution to journalArticle

Gohma, H, Kuramoto, T, Matalon, R, Surendran, S, Tyring, S, Kitada, K, Sasa, M & Serikawa, T 2007, 'Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice', Experimental Animals, vol. 56, no. 2, pp. 161-165. https://doi.org/10.1538/expanim.56.161
Gohma, Hiroshi ; Kuramoto, Takashi ; Matalon, Reuben ; Surendran, Sankar ; Tyring, Stephen ; Kitada, Kazuhiro ; Sasa, Masashi ; Serikawa, Tadao. / Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice. In: Experimental Animals. 2007 ; Vol. 56, No. 2. pp. 161-165.
@article{10387655cd2f45059342695218fd6a0b,
title = "Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice",
abstract = "The Spontaneously Epileptic Rat (SER), a double-mutant for tremor and zitter mutations, shows spontaneous occurrences of absence-like and tonic seizures. Several lines of evidence suggest that the combined effect of Aspa and Atrn mutations is the most likely cause of the epileptic phenotype of the SER. To address this issue, we produced a new double-mutant mouse line carrying both homozygous Aspa-knockout and Atrnmg-3J mutant alleles. The Aspa/Atrn double-mutant mice exhibited absence-like and tonic seizures that were characterized by the appearance of 5-7 Hz spike-wave-like complexes and low voltage fast waves on EEGs. These results demonstrate directly that the simultaneous loss of the Aspa and Atrn gene functions causes epileptic seizures in the mouse and suggest that both Aspa and Atrn deficiencies might be responsible for epileptic seizures in the SER.",
keywords = "Aspartoacylase, Attractin, Epilepsy",
author = "Hiroshi Gohma and Takashi Kuramoto and Reuben Matalon and Sankar Surendran and Stephen Tyring and Kazuhiro Kitada and Masashi Sasa and Tadao Serikawa",
year = "2007",
month = "4",
day = "26",
doi = "10.1538/expanim.56.161",
language = "English (US)",
volume = "56",
pages = "161--165",
journal = "Experimental Animals",
issn = "1341-1357",
publisher = "International Press Editing Centre Incorporation",
number = "2",

}

TY - JOUR

T1 - Absence-like and tonic seizures in aspartoacylase/attractin double-mutant mice

AU - Gohma, Hiroshi

AU - Kuramoto, Takashi

AU - Matalon, Reuben

AU - Surendran, Sankar

AU - Tyring, Stephen

AU - Kitada, Kazuhiro

AU - Sasa, Masashi

AU - Serikawa, Tadao

PY - 2007/4/26

Y1 - 2007/4/26

N2 - The Spontaneously Epileptic Rat (SER), a double-mutant for tremor and zitter mutations, shows spontaneous occurrences of absence-like and tonic seizures. Several lines of evidence suggest that the combined effect of Aspa and Atrn mutations is the most likely cause of the epileptic phenotype of the SER. To address this issue, we produced a new double-mutant mouse line carrying both homozygous Aspa-knockout and Atrnmg-3J mutant alleles. The Aspa/Atrn double-mutant mice exhibited absence-like and tonic seizures that were characterized by the appearance of 5-7 Hz spike-wave-like complexes and low voltage fast waves on EEGs. These results demonstrate directly that the simultaneous loss of the Aspa and Atrn gene functions causes epileptic seizures in the mouse and suggest that both Aspa and Atrn deficiencies might be responsible for epileptic seizures in the SER.

AB - The Spontaneously Epileptic Rat (SER), a double-mutant for tremor and zitter mutations, shows spontaneous occurrences of absence-like and tonic seizures. Several lines of evidence suggest that the combined effect of Aspa and Atrn mutations is the most likely cause of the epileptic phenotype of the SER. To address this issue, we produced a new double-mutant mouse line carrying both homozygous Aspa-knockout and Atrnmg-3J mutant alleles. The Aspa/Atrn double-mutant mice exhibited absence-like and tonic seizures that were characterized by the appearance of 5-7 Hz spike-wave-like complexes and low voltage fast waves on EEGs. These results demonstrate directly that the simultaneous loss of the Aspa and Atrn gene functions causes epileptic seizures in the mouse and suggest that both Aspa and Atrn deficiencies might be responsible for epileptic seizures in the SER.

KW - Aspartoacylase

KW - Attractin

KW - Epilepsy

UR - http://www.scopus.com/inward/record.url?scp=34248222605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34248222605&partnerID=8YFLogxK

U2 - 10.1538/expanim.56.161

DO - 10.1538/expanim.56.161

M3 - Article

VL - 56

SP - 161

EP - 165

JO - Experimental Animals

JF - Experimental Animals

SN - 1341-1357

IS - 2

ER -