Absorption of food protein antigen in infants with food protein-induced enterocolitis

Geraldine Keating Powell, Phillip J. McDonald, Greggory J. Van Sickle, Randall M. Goldblum

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Increased gastrointestinal absorption of intact antigen with systemic immunization has been considered a major etiologic factor in the development of food sensitivity. We attempted to test this hypothesis in infants with suspected food protein-induced enter colitis by measuring serum ovalbumin (OVA) concentrations after ingestion of egg white (prior to the performance of good challenges to establish this diagnosis). We first noted significant underestimation of serum OVA concentrations in the presence of even low serum anti-OVA antibody concentrations (>1:12). Next, using selected noninhibitory sera, we found that all infants studied absorbed some OVA, there was no correlation between serum OVA levels and age (3-11 months), and there was no significant difference between serum OVA concentrations in infants who subsequently had positive oral food challenge responses (120 ±67 ng/ml) and a matched group with negative challenges (102 ±80). These data do not support the hypothesis that "intestinal closure" (antigen exclusion) occurs in the neonatal period or the role of antigen absorption as the major etiological factor in the development of food sensitivity. Better methods of quantitating macromolecular absorption must be developed before the role of antigen absorption in food sensitivity can be assessed. Of note, urinary excretion of intact OVA also occurred. This varied greatly from one voiding to the next and continuing for at least 13 hr after ingestion.

Original languageEnglish (US)
Pages (from-to)781-788
Number of pages8
JournalDigestive Diseases and Sciences
Volume34
Issue number5
DOIs
StatePublished - May 1989

Fingerprint

Infant Food
Enterocolitis
Ovalbumin
Antigens
Food
Serum
Proteins
Eating
Egg White
Colitis
Anti-Idiotypic Antibodies
Immunization
Research Design

Keywords

  • food protein-induced enterocolitis
  • food sensitivity
  • infants
  • macromolecular absorption
  • ovalbumin

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Absorption of food protein antigen in infants with food protein-induced enterocolitis. / Powell, Geraldine Keating; McDonald, Phillip J.; Van Sickle, Greggory J.; Goldblum, Randall M.

In: Digestive Diseases and Sciences, Vol. 34, No. 5, 05.1989, p. 781-788.

Research output: Contribution to journalArticle

Powell, Geraldine Keating ; McDonald, Phillip J. ; Van Sickle, Greggory J. ; Goldblum, Randall M. / Absorption of food protein antigen in infants with food protein-induced enterocolitis. In: Digestive Diseases and Sciences. 1989 ; Vol. 34, No. 5. pp. 781-788.
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