The purpose of the study is to check the therapeutic capacities of exogenous application of glutathione and vitamins (B Complex and E) in the acceleration of metal elimination from different tissues of chromium intoxicated animals. For this, a model was developed, taking one day old chick as an experimental animal. Five groups of chicks were intoxicated with a daily dose of 10 mg/Kg of hexagonal chromium (potassium dichromate) for seven days. Thereafter, one group was screened for chromium content. The second group was kept without treatment for another seven days and sacrificed on 15th day, which was considered as withdrawal group. The other three groups were treated separately with a daily dose of vitamin B complex (20 mg/Kg), vitamin E (60 mg/Kg) and glutathione (50 mg/Kg), for another seven days. The animals were sacrificed on 15th day of their age. Controls were also maintained with each group and screened for chromium content. Our results show chromium elimination during toxicated, withdrawal and therapeutic treatment periods. However, as compared to toxicated group the animals of withdrawal group revealed one and half time more elimination, while the therapeutic groups showed two to three times more chromium elimination as recorded from the fecal matter analysis. The present study clearly shows that exogenous application of vitamins B Complex and E as well as GSH accelerates chromium elimination, which is absolutely necessary because the metal causes severe health hazards even during short stay in the body.
|Original language||English (US)|
|Number of pages||11|
|Journal||Research Communications in Pharmacology and Toxicology|
|State||Published - Jan 1 2001|
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