TY - JOUR
T1 - Access to 2,2-Halofluorobicyclo[1.1.1] Pentanes via Non Ozone-Depleting Ethyl Dihalofluoroacetate
AU - Zhu, Ziyue
AU - Tang, Jiaqi
AU - Coe, Matthew
AU - Knieb, Alexander
AU - Xu, Yijie
AU - Lin, Daniel
AU - Zhang, Chao
AU - Surya Prakash, G. K.
N1 - Publisher Copyright:
2025 The Author(s). Advanced Synthesis & Catalysis published by Wiley-VCH GmbH.
PY - 2025/3/18
Y1 - 2025/3/18
N2 - An operationally simple protocol to access 2,2-chlorofluoro-, and 2,2-bromofluorobicyclopentanes (BCPs) via commercially available, inexpensive, non-ozone depleting, and bench stable reagents is reported. The resulting BCP products are tolerated in diverse, synthetically relevant post-functionalization reactions. Gram-scale reactions to prepare the BCPs are also included.
AB - An operationally simple protocol to access 2,2-chlorofluoro-, and 2,2-bromofluorobicyclopentanes (BCPs) via commercially available, inexpensive, non-ozone depleting, and bench stable reagents is reported. The resulting BCP products are tolerated in diverse, synthetically relevant post-functionalization reactions. Gram-scale reactions to prepare the BCPs are also included.
KW - 2-halofluorobicyclopentanes
KW - Bromofluorocarbene
KW - Chlorofluorocarbene
KW - Ethyl dibromofluoroacetate
KW - Ethyl dichlorofluoroacetate
UR - https://www.scopus.com/pages/publications/105001065886
UR - https://www.scopus.com/pages/publications/105001065886#tab=citedBy
U2 - 10.1002/adsc.202401475
DO - 10.1002/adsc.202401475
M3 - Article
AN - SCOPUS:105001065886
SN - 1615-4150
VL - 367
JO - Advanced Synthesis and Catalysis
JF - Advanced Synthesis and Catalysis
IS - 6
M1 - e202401475
ER -