Accuracy of common drug screen tests

Joyce G. Schwartz, Philip R. Zollars, Anthony Okorodudu, Joyce J. Carnahan, Jack E. Wallace, John E. Briggs

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Forty consecutive urine specimens, obtained from patients seen in the emergency center, positive for either cocaine and/or marijuana, were analyzed using five methods of analysis. A new latex agglutination inhibition assay, Abuscreen OnTrak, (Roche Diagnostic Systems, Nutley, NJ), was compared with four other drug abuse assays: mass spectrometry, (Hewlett-Packard Co, Richardson, TX); an automated homogeneous enzyme immunoassay technique, ETS System, (Syva Co, Palo Alto, CA); a manual enzyme multiplied immunoassay technique; EMIT-st, (Syva); and a fluorescence polarization immunoassay, TDx, (Abbott Laboratories, Chicago, IL). For statistical purposes, mass spectrometry was the reference point for the presence or absence of a specific substance. All instrument sensitivities, with the exception of mass spectromatry, were set with the same "cut off" point of 100 μg/L for marijuana and 300 μg/L for cocaine and its metabolites. Efficiency in the detection of cocaine and its metabolites was 95% by all methods. Efficiency for the detection of marijuana and its metabolites ranged from 70% (Roche's OnTrak) to 90% (Syva's ETS). Simple to use, assays of minimal cost are presently available for rapid, accurate drug of abuse screening.

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalAmerican Journal of Emergency Medicine
Volume9
Issue number2
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Cannabis
Cocaine
Mass Spectrometry
Substance Abuse Detection
Enzyme Multiplied Immunoassay Technique
Pharmaceutical Preparations
Fluorescence Polarization Immunoassay
Efficiency
Agglutination
Latex
Street Drugs
Immunoenzyme Techniques
Substance-Related Disorders
Emergencies
Urine
Costs and Cost Analysis

Keywords

  • cannabis
  • Cocaine
  • street drugs
  • substance abuse

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Schwartz, J. G., Zollars, P. R., Okorodudu, A., Carnahan, J. J., Wallace, J. E., & Briggs, J. E. (1991). Accuracy of common drug screen tests. American Journal of Emergency Medicine, 9(2), 166-170. https://doi.org/10.1016/0735-6757(91)90184-L

Accuracy of common drug screen tests. / Schwartz, Joyce G.; Zollars, Philip R.; Okorodudu, Anthony; Carnahan, Joyce J.; Wallace, Jack E.; Briggs, John E.

In: American Journal of Emergency Medicine, Vol. 9, No. 2, 1991, p. 166-170.

Research output: Contribution to journalArticle

Schwartz, JG, Zollars, PR, Okorodudu, A, Carnahan, JJ, Wallace, JE & Briggs, JE 1991, 'Accuracy of common drug screen tests', American Journal of Emergency Medicine, vol. 9, no. 2, pp. 166-170. https://doi.org/10.1016/0735-6757(91)90184-L
Schwartz, Joyce G. ; Zollars, Philip R. ; Okorodudu, Anthony ; Carnahan, Joyce J. ; Wallace, Jack E. ; Briggs, John E. / Accuracy of common drug screen tests. In: American Journal of Emergency Medicine. 1991 ; Vol. 9, No. 2. pp. 166-170.
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