Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Alexander I. Kholodnykh; Kamran Hosseini; Kirill V. Larin; Alexandra A. Vassilieva; Rinat O. Esenaliev; Massoud Motamedi

doi:10.1117/12.533356

Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Alexander I. Kholodnykh, Kamran Hosseini, Kirill V. Larin, Alexandra A. Vassilieva, Rinat O. Esenaliev, Massoud Motamedi

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscatteriag as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

Original language	English (US)
Pages (from-to)	12-15
Number of pages	4
Journal	Proceedings of SPIE - The International Society for Optical Engineering
Volume	5316
DOIs	https://doi.org/10.1117/12.533356
State	Published - 2004
Event	Progress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII - San Jose, CA, United States Duration: Jan 26 2004 → Jan 28 2004

Keywords

Corneal backscattering
Corneal hydration control
Corneal thickness
Noninvasive monitoring
OCT

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Computer Science Applications
Applied Mathematics
Electrical and Electronic Engineering

Access to Document

10.1117/12.533356

Cite this

Kholodnykh, A. I., Hosseini, K., Larin, K. V., Vassilieva, A. A., Esenaliev, R. O., & Motamedi, M. (2004). Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. Proceedings of SPIE - The International Society for Optical Engineering, 5316, 12-15. https://doi.org/10.1117/12.533356

Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. / Kholodnykh, Alexander I.; Hosseini, Kamran; Larin, Kirill V. et al.
In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 5316, 2004, p. 12-15.

Research output: Contribution to journal › Conference article › peer-review

Kholodnykh, AI, Hosseini, K, Larin, KV, Vassilieva, AA, Esenaliev, RO & Motamedi, M 2004, 'Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states', Proceedings of SPIE - The International Society for Optical Engineering, vol. 5316, pp. 12-15. https://doi.org/10.1117/12.533356

@article{84f122f96e954662b2e6877eba980edb,

title = "Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states",

abstract = "Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscatteriag as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.",

keywords = "Corneal backscattering, Corneal hydration control, Corneal thickness, Noninvasive monitoring, OCT",

author = "Kholodnykh, {Alexander I.} and Kamran Hosseini and Larin, {Kirill V.} and Vassilieva, {Alexandra A.} and Esenaliev, {Rinat O.} and Massoud Motamedi",

year = "2004",

doi = "10.1117/12.533356",

language = "English (US)",

volume = "5316",

pages = "12--15",

journal = "Proceedings of SPIE - The International Society for Optical Engineering",

issn = "0277-786X",

publisher = "SPIE",

note = "Progress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII ; Conference date: 26-01-2004 Through 28-01-2004",

}

TY - JOUR

T1 - Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

AU - Kholodnykh, Alexander I.

AU - Hosseini, Kamran

AU - Larin, Kirill V.

AU - Vassilieva, Alexandra A.

AU - Esenaliev, Rinat O.

AU - Motamedi, Massoud

PY - 2004

Y1 - 2004

N2 - Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscatteriag as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

AB - Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscatteriag as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

KW - Corneal backscattering

KW - Corneal hydration control

KW - Corneal thickness

KW - Noninvasive monitoring

KW - OCT

UR - http://www.scopus.com/inward/record.url?scp=5644235556&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=5644235556&partnerID=8YFLogxK

U2 - 10.1117/12.533356

DO - 10.1117/12.533356

M3 - Conference article

AN - SCOPUS:5644235556

SN - 0277-786X

VL - 5316

SP - 12

EP - 15

JO - Proceedings of SPIE - The International Society for Optical Engineering

JF - Proceedings of SPIE - The International Society for Optical Engineering

T2 - Progress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII

Y2 - 26 January 2004 through 28 January 2004

ER -

Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this