Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states

Alexander I. Kholodnykh, Kamran Hosseini, Kirill V. Larin, Alexandra A. Vassilieva, Rinat Esenaliev, Massoud Motamedi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Recently we reported measurements of the corneal in-depth light backscattering distribution (CDLBD) by optical coherence tomography (OCT) as a possible tool for investigation of the corneal hydration and estimation of water gradients inside the cornea. In this paper, we present additional results demonstrating a strong correlation (R = 0.99) between the amplitude of light backscattering as measured by OCT and the corneal thickness. In contrary to the well-known effect of the immediate increase observed in corneal opacity during corneal swelling, we observed an initial decrease of the amplitude of light backscatteriag as measured by OCT in the anterior part of the stroma during the swelling process. The possible explanation for this observation is discussed. Also methodological improvements for accurate measurements of the CDLBD in vivo are outlined.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V. Tuchin, J.A. Izatt, J.G. Fujimoto
Pages12-15
Number of pages4
Volume5316
DOIs
StatePublished - 2004
EventProgress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII - San Jose, CA, United States
Duration: Jan 26 2004Jan 28 2004

Other

OtherProgress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII
CountryUnited States
CitySan Jose, CA
Period1/26/041/28/04

Fingerprint

Optical tomography
Backscattering
Hydration
hydration
backscattering
tomography
swelling
Swelling
cornea
Opacity
opacity
gradients
water
Water

Keywords

  • Corneal backscattering
  • Corneal hydration control
  • Corneal thickness
  • Noninvasive monitoring
  • OCT

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Kholodnykh, A. I., Hosseini, K., Larin, K. V., Vassilieva, A. A., Esenaliev, R., & Motamedi, M. (2004). Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5316, pp. 12-15) https://doi.org/10.1117/12.533356

Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. / Kholodnykh, Alexander I.; Hosseini, Kamran; Larin, Kirill V.; Vassilieva, Alexandra A.; Esenaliev, Rinat; Motamedi, Massoud.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V. Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 5316 2004. p. 12-15.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kholodnykh, AI, Hosseini, K, Larin, KV, Vassilieva, AA, Esenaliev, R & Motamedi, M 2004, Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5316, pp. 12-15, Progress in Biomedical Optics and Imaging - Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, San Jose, CA, United States, 1/26/04. https://doi.org/10.1117/12.533356
Kholodnykh AI, Hosseini K, Larin KV, Vassilieva AA, Esenaliev R, Motamedi M. Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5316. 2004. p. 12-15 https://doi.org/10.1117/12.533356
Kholodnykh, Alexander I. ; Hosseini, Kamran ; Larin, Kirill V. ; Vassilieva, Alexandra A. ; Esenaliev, Rinat ; Motamedi, Massoud. / Accurate in vivo measurements of the corneal light backscattering in-depth distribution with optical coherence tomography for different hydration states. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V. Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 5316 2004. pp. 12-15
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